Month: October 2022

Ji, Danyang; Lyu, Kaixin; Zhao, Haizhou; Kwok, Chun Kit published their research in Nucleic Acids Research in 2021. The article was titled 《Circular L-RNA aptamer promotes target recognition and controls gene activity》.Related Products of 510758-28-8 The article contains the following contents:

Rational design of aptamers to incorporate unnatural nucleotides and special chem. moieties can expand their functional complexity and diversity. Spiegelmer (L-RNA aptamer) is a unique class of aptamer that is composed of unnatural L-RNA nucleotides, and so far there are limited L-RNA aptamer candidates and applications being reported. Moreover, the target binding properties of current L-RNA aptamers require significant improvement. Here, using L-Apt.4-1c as an example, we develop a simple and robust strategy to generate the first circular L-RNA aptamer, cycL-Apt.4-1c, quant., demonstrate substantial enhancement in binding affinity and selectivity toward its target, and notably report novel applications of circular L-RNA aptamer in controlling RNA-protein interaction, and gene activity including telomerase activity and gene expression. Our approach and findings will be applicable to any L-RNA aptamers and open up a new avenue for diverse applications. In the experiment, the researchers used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Related Products of 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Related Products of 510758-28-8Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Yakovlieva, Liubov; Wood, Thomas M.; Kemmink, Johan; Kotsogianni, Ioli; Koller, Franziska; Lassak, Juergen; Martin, Nathaniel I.; Walvoort, Marthe T. C. published an article in 2021. The article was titled 《A β-hairpin epitope as novel structural requirement for protein arginine rhamnosylation》, and you may find the article in Chemical Science.Synthetic Route of C12H22F6N6OP2 The information in the text is summarized as follows:

For canonical asparagine glycosylation, the primary amino acid sequence that directs glycosylation at specific asparagine residues is well-established. Here we reveal that a recently discovered bacterial enzyme EarP, that transfers rhamnose to a specific arginine residue in its acceptor protein EF-P, specifically recognizes a β-hairpin loop. Notably, while the in vitro rhamnosyltransferase activity of EarP is abolished when presented with linear substrate peptide sequences derived from EF-P, the enzyme readily glycosylates the same sequence in a cyclized β-hairpin mimic. Addnl. studies with other substrate-mimicking cyclic peptides revealed that EarP activity is sensitive to the method used to induce cyclization and in some cases is tolerant to amino acid sequence variation. Using detailed NMR approaches, we established that the active peptide substrates all share some degree of β-hairpin formation, and therefore conclude that the β-hairpin epitope is the major determinant of arginine-rhamnosylation by EarP. Our findings add a novel recognition motif to the existing knowledge on substrate specificity of protein glycosylation, and are expected to guide future identifications of rhamnosylation sites in other protein substrates. The experimental process involved the reaction of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Synthetic Route of C12H22F6N6OP2)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.Synthetic Route of C12H22F6N6OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amineIn 2020 ,《Dissipative self-assembly, competition and inhibition in a self-reproducing protocell model》 was published in Chemical Science. The article was written by Post, Elias A. J.; Fletcher, Stephen P.. The article contains the following contents:

The bottom-up synthesis of artificial, life-like systems promises to enable the study of emergent properties distinctive to life. Here, we report protocell systems generated from phase-separated building blocks. Vesicle protocells self-reproduce through a phase-transfer mechanism, catalyzing their own formation. Dissipative self-assembly by the protocells is achieved when a hydrolysis step to destroy the surfactant is introduced. Competition between micelle and vesicle based replicators for a common feedstock shows that environmental conditions can control what species predominates: under basic conditions vesicles predominate, but in a neutral medium micelles are selected for via a mechanism which inhibits vesicle formation. Finally, the protocells enable orthogonal reactivity by catalyzing in situ formation of an amphiphilic organocatalyst, which after incorporation into the vesicle bilayer enantioselectively forms a secondary product. The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 510758-28-8In 2021 ,《Simple chemical detection based on a surface-modified electroosmotic pump via interval immobilization》 was published in Analytical Methods. The article was written by Naito, Toyohiro; Inoue, Hiroki; Kubo, Takuya; Otsuka, Koji. The article contains the following contents:

Environmental water quality monitoring plays an important role in human health risk assessments for pharmaceuticals in water and pollutant source control. A new chem. detection method was developed to enhance mol. selectivity and portability by combining the molecularly imprinted technique and an electroosmotic pump (EOP), which requires only a small pump, batteries and stopwatch in principle. Selective chem. adsorption on the surface-modified EOP decreases the pumping performance of EOP due to a decrease in the surface elec. charge. For proof of concept, the microfabricated EOPs with chem. surface treatment were used to investigate the effects of surface chem. change on pumping performance. The microfluidic EOP of a size of 20 mm x 20 mm x 1 mm was modified by an interval immobilization method using the template of 4-(tributylammonium-methyl)-benzyltributylammonium chloride (TBTA) and evaluated by measuring EOF. The pumping performance of the surface-modified EOP was decreased by the selective adsorption of TBTA to a two-point recognition site on the EOP surfaces. The relationships between the flow rate and the TBTA concentration were fitted to the Langmuir equation. The EOP can selectively detect the model substance even in a mixture solution with a different chem. compound This mol. imprinted EOP does not require large and expensive instruments for driving the device and chem. detection, which can be applied to a portable anal. device for onsite anal. The results came from multiple reactions, including the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Related Products of 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Related Products of 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Synthesis of 1,2,3-triazole group-containing isomannide-based aromatic new polyurethanes》 was written by Bayrak, Fatih; Ay, Emriye; Oral, Ayhan; Karayildirim, Tamer; Ay, Kadir. Name: 1H-1,2,3-TriazoleThis research focused ontriazole group isomannide aromatic polyurethane surface property. The article conveys some information:

Ten new carbohydrate-based aromatic polyurethanes have been synthesized using isomannide and/or a new 1,2,3-triazole isomannide derivative, IV, as the diol source in the polymerization reactions. As the isocyanate source, 1,4-phenylene diisocyanate or 2,4-toluene diisocyanate was used. To synthesize compound IV, isomannide was tosylated, the tosyl groups were substituted with azide, the triazole ring was formed by reaction with 2,4-pentane dione and finally carbonyl groups were converted into oximes. The synthesis of copolymers and terpolymers was performed using different proportions of diisocyanate and diol sources in DMF. The structural elucidation of the synthesized compounds and polymers was performed using spectroscopic techniques such as FTIR, 1D- and 2D-NMR and HRMS. The thermal behavior and mol. weight distribution of polymers were analyzed by thermal gravimetric anal. and gel permeation chromatog., resp. The surface properties of the polymers were analyzed using SEM. A comparative study on thermal behavior of the synthesized polymers showed that polymers containing a higher amount of compound IV displayed better thermal stability. The average mol. weights of copolymers were observed to vary from 7,900 (PUR-3) to 21,000 (PUR-4) whereas for terpolymers, values of 19,000 (PUR-5), 5,100 (PUR-6), 22,000 (PUR-8) and 28,000 (PUR-9) were found. The diisocyanate source was found to have more effect on the surface properties of polymers than the diol source: when 2,4-toluene diisocyanate was used in polymer synthesis, the resultant polymers had a spongy morphol. with cavities while a polymer matrix containing spheres and platelets was obtained when 1,4-toluene diisocyanate was used. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Name: 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Name: 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2015,Berchel, Mathieu; Haddad, Jimmy; Le Corre, Stephanie S.; Haelters, Jean-Pierre; Jaffres, Paul-Alain published 《Synthesis of lipid-based unsymmetrical O,O-dialkylphosphites》.Tetrahedron Letters published the findings.Formula: C12H22F6N6OP2 The information in the text is summarized as follows:

An efficient method for the synthesis of unsym. lipid-based O,O-dialkylphosphites is reported. The reaction implies the use of H-phosphonates monoester ammonium salt which is coupled with a fatty alc. in the presence of an optimized quantity of pivaloyl chloride (Piv-Cl) as coupling reagent. The reaction conditions offer access to a wide panel of unsym. O,O-dialkylphosphites including either non-functionalized lipid derivatives (lauryl, dodecyl tetradecyl, hexadecyl, octadecyl), lipid (phytanyl), unsaturated lipids (oleyl, linoleyl) or ω-functionalized alkyl alcs. (azide, propargyl, alkenyl). The experimental part of the paper was very detailed, including the reaction process of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Formula: C12H22F6N6OP2)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Formula: C12H22F6N6OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2016,Hu, Bei-Bei; Yuan, Yue; Zhou, Xiao-Ping; Li, San-Ming published 《Synthesis and properties of a novel bolaamphiphile surfactant derived from proline》.Chinese Chemical Letters published the findings.COA of Formula: C12H22F6N6OP2 The information in the text is summarized as follows:

A novel bolaamphiphile surfactant N,N’-(octane-1,8-diyl)bis(pyrrolidine-2-carboxamide) (DAOP), was designed and synthesized from proline and 1,8-diaminooctane, as the hydrophilic part and hydrophobic part, resp. After separation and purification, the structures of the synthesized bola surfactants were verified by IR, MS and 1H NMR. The pKa was measured by a titration experiment, the turbidity was determined using a Shimadzu UV-1750 spectrophotometer, and the critical micelle concentration (CMC) values of the synthesized surfactants in water were obtained using the conductivity and fluorescence probe measurements. The synthesized bolaamphiphile surfactants demonstrate the ability of self-assemble to form vesicles that were confirmed with dynamic light scattering and transmission electron microscopy. The results showed that the novel bolaamphiphile surfactant derived from proline might potentially be an excellent carrier for drug delivery. In the experimental materials used by the author, we found ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6COA of Formula: C12H22F6N6OP2)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.COA of Formula: C12H22F6N6OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2017,Fay, Francois; Hansen, Line; Hectors, Stefanie J. C. G.; Sanchez-Gaytan, Brenda L.; Zhao, Yiming; Tang, Jun; Munitz, Jazz; Alaarg, Amr; Braza, Mounia S.; Gianella, Anita; Aaronson, Stuart A.; Reiner, Thomas; Kjems, Joergen; Langer, Robert; Hoeben, Freek J. M.; Janssen, Henk M.; Calcagno, Claudia; Strijkers, Gustav J.; Fayad, Zahi A.; Perez-Medina, Carlos; Mulder, Willem J. M. published 《Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging》.Bioconjugate Chemistry published the findings.Application of 56602-33-6 The information in the text is summarized as follows:

Active targeting of nanoparticles through surface functionalization is a common strategy to enhance tumor delivery specificity. However, active targeting strategies tend to work against long polyethylene glycol’s shielding effectiveness and associated favorable pharmacokinetics. To overcome these limitations, we developed a matrix metalloproteinase-2 sensitive surface-converting polyethylene glycol coating. This coating prevents nanoparticle-cell interaction in the bloodstream, but, once exposed to matrix metalloproteinase-2, i.e., when the nanoparticles accumulate within the tumor interstitium, the converting polyethylene glycol coating is cleaved, and targeting ligands become available for binding to tumor cells. In this study, we applied a comprehensive multimodal imaging strategy involving optical, nuclear, and magnetic resonance imaging methods to evaluate this coating approach in a breast tumor mouse model. The data obtained revealed that this surface-converting coating enhances the nanoparticle’s blood half-life and tumor accumulation and ultimately results in improved tumor-cell targeting. Our results show that this enzyme-sp. surface-converting coating ensures a high cell-targeting specificity without compromising favorable nanoparticle pharmacokinetics. After reading the article, we found that the author used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Application of 56602-33-6)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.Application of 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,RSC Advances included an article by Zaitsev-Doyle, John J.; Puchert, Anke; Pfeifer, Yannik; Yan, Hao; Yorke, Briony A.; Mueller-Werkmeister, Henrike M.; Uetrecht, Charlotte; Rehbein, Julia; Huse, Nils; Pearson, Arwen R.; Sans, Marta. Related Products of 510758-28-8. The article was titled 《Synthesis and characterization of α-carboxynitrobenzyl photocaged L-aspartates for applications in time-resolved structural biology》. The information in the text is summarized as follows:

We report a new synthetic route to a series of α-carboxynitrobenzyl photocaged L-aspartates for application in time-resolved structural biol. The resulting compounds were characterised in terms of UV/Vis absorption properties, aqueous solubility and stability, and photocleavage rates (τ = μs to ms) and quantum yields (φ = 0.05 to 0.14). The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Related Products of 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Related Products of 510758-28-8Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Watt, Fabian A.; Sieland, Benedikt; Dickmann, Nicole; Schoch, Roland; Herbst-Irmer, Regine; Ott, Holger; Paradies, Jan; Kuckling, Dirk; Hohloch, Stephan published an article in 2021. The article was titled 《Coupling of CO2 and epoxides catalysed by novel N-fused mesoionic carbene complexes of nickel(II)》, and you may find the article in Dalton Transactions.Synthetic Route of C30H30N10 The information in the text is summarized as follows:

Syntheses of two rigid mesoionic carbene (MIC) ligands with a carbazole backbone via an intramol. Finkelstein-cyclization cascade and investigate their coordination behavior toward nickel(II) acetate. Despite the nickel(II) carbene complexes showed only minor differences in their chem. composition, they displayed curious differences in their chem. properties, e.g. solubility Furthermore, the potential of these novel MIC complexes in the coupling of carbon dioxide and epoxides to afford dioxolanone derivatives I [R = OCH2CH=CH2, CH2CH=CH2, NHBOC, etc.] and the differences in reactivity compared to classical NHC-derived complexes were evaluated.Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Synthetic Route of C30H30N10) was used in this study.

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Synthetic Route of C30H30N10

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics