Month: October 2022

Electric Literature of C2H3N3In 2022 ,《Rational design of Striga hermonthica-specific seed germination inhibitors》 was published in Plant Physiology. The article was written by Zarban, Randa A.; Hameed, Umar F. Shahul; Jamil, Muhammad; Ota, Tsuyoshi; Wang, Jian You; Arold, Stefan T.; Asami, Tadao; Al-Babili, Salim. The article contains the following contents:

The obligate hemiparasitic weed Striga hermonthica grows on cereal roots and presents a severe threat to global food security by causing enormous yield losses, particularly in sub-Saharan Africa. The rapidly increasing Striga seed bank in infested soils provides a major obstacle in controlling this weed. Striga seeds require host-derived strigolactones (SLs) for germination, and corresponding antagonists could be used as germination inhibitors. Recently, we demonstrated that the common detergent Triton X-100 is a specific inhibitor of Striga seed germination by binding noncovalently to its receptor, S. hermonthica HYPO-SENSITIVE TO LIGHT 7 (ShHTL7), without blocking the rice (Oryza sativa) SL receptor DWARF14 (OsD14). Moreover, triazole ureas, the potent covalently binding antagonists of rice SL perception with much higher activity toward OsD14, showed inhibition of Striga but were less specific. Considering that Triton X-100 is not suitable for field application and by combining structural elements of Triton and triazole urea, we developed two hybrid compounds, KK023-N1 and KK023-N2, as potential Striga-specific germination inhibitors. Both compounds blocked the hydrolysis activity of ShHTL7 but did not affect that of OsD14. Binding of KK023-N1 diminished ShHTL7 interaction with S. hermonthica MORE AXILLARY BRANCHING 2, a major component in SL signal transduction, and increased ShHTL7 thermal specificity. Docking studies indicate that KK023-N1 binding is not covalent but is caused by hydrophobic interactions. Finally, in vitro and greenhouse tests revealed specific inhibition of Striga seed germination, which led to a 38% reduction in Striga infestation in pot experiments These findings reveal that KK023-N1 is a potential candidate for combating Striga and a promising basis for rational design and development of further Striga-specific herbicides.1H-1,2,3-Triazole(cas: 288-36-8Electric Literature of C2H3N3) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Electric Literature of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of C12H22F6N6OP2In 2017 ,《First identification and quantification of S-3-(hexan-1-ol)-γ-glutamyl-cysteine in grape must as a potential thiol precursor, using UPLC-MS/MS analysis and stable isotope dilution assay》 was published in Food Chemistry. The article was written by Bonnaffoux, Hugo; Roland, Aurelie; Remond, Emmanuelle; Delpech, Stephane; Schneider, Remi; Cavelier, Florine. The article contains the following contents:

Varietal thiols are key aroma compounds in wine issued from multiple and complex origins. Several precursor families have been identified in grapes and must and have been widely studied. But a large part of thiol origin still remains unknown. Thus, we only have an incomplete picture of thiol precursors and there is a lack of knowledge on pre-fermentative mechanisms that can impact their levels. Our study focused on the formal identification and the quantification of new varietal thiol precursors in must. First of all, we synthesized natural and labeled standards using an original multi-step strategy, then we developed and validated a UPLC-MS/MS method that allowed us to identify and quantify for the first time a dipeptide S-conjugate to 3MH, the γGluCys-3MH, in Sauvignon B. We observed the S-4-mercapto-4-methylpentan-2-one-L-cysteinyl-glycine (CysGly-4MMP) and S-4-mercapto-4-methylpentan-2-one-N-(L-γ-glutamyl)-L-cysteine (γGluCys-4MMP) but at too low concentration to be quantified. In the experiment, the researchers used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Electric Literature of C12H22F6N6OP2)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Electric Literature of C12H22F6N6OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2016,Vemula, Sandeep R.; Kumar, Dinesh; Cook, Gregory R. published 《Palladium-Catalyzed Allylic Amidation with N-Heterocycles via sp3 C-H Oxidation》.ACS Catalysis published the findings.Category: triazoles The information in the text is summarized as follows:

An atom-economic direct intermol. allylic amidation of electron-deficient tautomerizable N-heterocycles is reported via allylic C-H activation of terminal olefins with a PdCl2 catalyst. The reaction did not require any activators (base or Lewis acid) or external ligands and proceeded with high chemo- (N vs O), regio- (linear vs branched), and stereoselectivity (E vs Z) for a variety of N-heterocycles and terminal olefins. Mechanistic investigation and stoichiometric studies validate the sulfoxide-ligand-assisted allylic C-H bond cleavage to form a π-allylpalladium intermediate in the reaction pathway. Excellent selectivity was observed during intermol. competition demonstrating the differential nucleophilicity of N-heterocycles and differential susceptibility of allyl C-H bond cleavage to form π-allylpalladium complexes directly from terminal olefins. In the experiment, the researchers used many compounds, for example, ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Category: triazoles)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《Hexadecanuclear MnII2MnIII14 Molecular Torus Built from in Situ Tandem Ligand Transformations》 were Riaz, Muhammad; Gupta, Rakesh Kumar; Su, Hai-Feng; Jaglicic, Zvonko; Kurmoo, Mohamedally; Tung, Chen-Ho; Sun, Di; Zheng, Lan-Sun. And the article was published in Inorganic Chemistry in 2019. Formula: C2H3N3 The author mentioned the following in the article:

A mixed-valent hexadecanuclear manganese cluster, [MnII2MnIII14(trz)14(thetach)4(μ3-O)8(H2O)10](ClO4)6 (Mn16), containing two MnII and 14 MnIII ions, is constructed from mixed in situ generated ligands, 1,2,3-triazole (Htrz) and 1,3,5-tri(2-hydroxyethyl)-1,3,5-triazacyclohexane (H3thetach). Remarkably, both ligands were not initially added into the reaction system, and their formations involve the in situ ligand decomposition and subsequent condensation reactions. The core of Mn16 is an elongated torus comprised of eight Mn atoms and four [Mn2O2] subunits bridged by oxo or alkoxide. The high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) of Mn16 dissolved in CH3CN indicates its structure remains intact as +3 and +4 species. Temperature and field dependent magnetization revealed predominantly antiferromagnetic exchange interactions within the cluster. The work provides 1-pot synthesis of high-nuclearity manganese clusters using the ligands generated by in situ reactions in a tandem fashion. A new strategy was uncovered consisting of a tandem in situ formation of two ligands which subsequently construct a hexadecanuclear mixed-valent manganese sym. torus. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Formula: C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Formula: C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Synthesis, optimization, antifungal activity, selectivity, and CYP51 binding of new 2-aryl-3-azolyl-1-indolyl-propan-2-ols》 was published in Pharmaceuticals in 2020. These research results belong to Lebouvier, Nicolas; Pagniez, Fabrice; Na, Young Min; Shi, Da; Pinson, Patricia; Marchivie, Mathieu; Guillon, Jean; Hakki, Tarek; Bernhardt, Rita; Yee, Sook Wah; Simons, Claire; Leze, Marie-Pierre; Hartmann, Rolf W.; Mularoni, Angelique; Le Baut, Guillaume; Krimm, Isabelle; Abagyan, Ruben; Le Pape, Patrice; Le Borgne, Marc. Safety of 1H-1,2,3-Triazole The article mentions the following:

A series of 2-aryl-3-azolyl-1-indolyl-propan-2-ols was designed as new analogs of fluconazole in two different chem. approaches. The first one, in seven steps, involved the synthesis of the key intermediate 1-(1H-benzotriazol-1-yl)methyl-1H-indole and the final opening of oxiranes by imidazole or 1H-1,2,4-triazole. The second route allowed access to the target compounds in only three steps, this time with the ring opening by indole and analogs. Twenty azole derivatives were tested against Candida albicans and other Candida species. The enantiomers of the best anti-Candida compound, 2-(2,4-dichlorophenyl)-3-(1H-indol-1-yl)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol, were analyzed by X-ray diffraction to determine their absolute configuration. The S-isomer (MIC = IC80 = 0.000256μg/mL on C. albicans CA98001) was found with the S-absolute configuration. In contrast the R-isomer was (MIC = 0.023μg/mL). Addnl., mol. docking calculations and mol. dynamics simulations were carried out using a crystal structure of Candida albicans lanosterol 14α-demethylase (CaCYP51). The S-isomer aligned with the positioning of posaconazole within both the heme and access channel binding sites, which was consistent with its biol. results. All target compounds have been also studied against human fetal lung fibroblast (MRC-5) cells. Finally, the selectivity of four compounds on a panel of human P 450-dependent enzymes (CYP19, CYP17, CYP26A1, CYP11B1, and CYP11B2) was investigated. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8Safety of 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Safety of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Two ways of spin crossover in an iron(II) coordination polymer associated with conformational changes of a bridging ligand》 was published in Dalton Transactions in 2020. These research results belong to Ksiazek, Maria; Weselski, Marek; Dreczko, Agnieszka; Maliuzhenko, Vladyslav; Kazmierczak, Marcin; Toloczko, Aleksandra; Kusz, Joachim; Bronisz, Robert. Name: 1H-1,2,3-Triazole The article mentions the following:

1,4-Di(1-ethyl-1,2,3-triazol-5-yl)butane (bbtre) was prepared by lithiation of 1-ethyl-1,2,3-triazole, followed by alkylation with 1,4-dibromobutane. The ligand bbtre forms a three-dimensional network with Fe(II), [Fe(bbtre)3](ClO4)2·2CH3CN, that exhibits thermally induced spin crossover (SCO). A change of temperature or change of spin state results in various types of structural transformation, leading to different structures that are stable in strictly defined temperature ranges. As a result, there are three spin crossover transitions arranged via two different paths. Thus, cooling <280 K involves a HT(HS) → LT(HS) (HT, high temperature structure; LT, low temperature structure; HS, high spin) phase transition (PT), which is associated with conformational changes of the bbtre mols. and with deformation of the polymeric skeleton. In the LT phase incomplete and reversible LT(HS) ⇄ LT(HS/LS) spin crossover occurs (LS, low spin). In contrast, rapid cooling (of a sample not previously thermally treated) allows the HT(HS) → LT(HS) phase transition to be avoided, and so complete HT(HS) → HT1(LS) SCO occurs. This means that the PT plays the role of a switch, which allows a choice of one of two ways in which the SCO will proceed. After rapid cooling, further heating to 150 K and subsequent cooling results in a reversible HT1(HS) ⇄ HT1(LS) spin crossover (T↓1/2 = 130 K, T↑1/2 = 131 K). However, raising the temperature to 170-200 K gives a modulated structure HT2(HS) exhibiting the next reversible HT2(HS) ⇄ HT2(LS) SCO (T↓1/2 = 121 K, T↑1/2 = 123 K). Finally, heating >200 K involves the HT2(HS) → LT(HS) PT and results in a LT(HS) structure exhibiting incomplete LT(HS) ⇄ LT(HS/LS) spin crossover. In the experimental materials used by the author, we found 1H-1,2,3-Triazole(cas: 288-36-8Name: 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Name: 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Cooperative Large-Hysteresis Spin-Crossover Transition in the Iron(II) Triazolate [Fe(ta)2] Metal-Organic Framework》 was written by Grzywa, Maciej; Roess-Ohlenroth, Richard; Muschielok, Christoph; Oberhofer, Harald; Blachowski, Artur; Zukrowski, Jan; Vieweg, Dana; von Nidda, Hans-Albrecht Krug; Volkmer, Dirk. Product Details of 288-36-8 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

The metal-organic framework [Fe(ta)2] (Hta = 1H-1,2,3-triazole) containing Fe(II) ions and 1,2,3-triazolate ligands shows a reversible phase transition while retaining the cubic crystal symmetry and space group Fd3m. The phase transition between room temperature (RT-[Fe(ta)2]; a 16.6315(2) Å, V = 4600.39(8) Å3) and high temperature (HT-[Fe(ta)2]; a 17.7566(4) Å, V = 5598.6(1) Å3) phases occurs at a temperature >290°, whereas the phase transition between HT- and RT-[Fe(ta)2] starts at a temperature <210°. Both [Fe(ta)2] polymorphs have identical bond topologies, but they differ by a large increase of the unit cell's volume of 22% for HT-[Fe(ta)2]. The compounds were characterized by powder x-ray diffraction, DSC, and thermogravimetric analyses. Addnl., Mossbauer spectroscopy, magnetic studies, and the electronic structure of both phases are discussed in detail with respect to the spin-crossover transition from the low-spin (RT-[Fe(ta)2]) to the high-spin phase (HT-[Fe(ta)2]). The metal-organic framework [Fe(ta)2] (Hta = 1H-1,2,3-triazole) shows a reversible coordinative wide-hysteresis phase transition >290° without change of the cubic crystal system and space group. A large difference in the unit cell lengths is observed between the low-spin RT-[Fe(ta)2] (a 16.6315(2) Å, V = 4600.39(8) Å3) and high-spin HT-[Fe(ta)2] (a 17.7566(4) Å, V = 5598.6(1) Å3) phases, which were studied in detail by Mossbauer spectroscopy, DSC, and VT-PXRD. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8Product Details of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Product Details of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2022,Aoyama, Takuma; Kato, Kazuaki; Urayama, Kenji published an article in ACS Macro Letters. The title of the article was 《Marked Sensitivity of Ultimate Elongation to Loading Axiality in Polyrotaxane Gels with Largely Slidable Cross Links》.Formula: C12H22F6N6OP2 The author mentioned the following in the article:

Polyrotaxane (PR) gels with low ring densities have figure-of-eight crosslinks that can slide along network strands. The slidable crosslinks have a unique ability to increase the network strand length between adjacent crosslinks in the loading direction via chain supply from the stress-free direction, thereby enhancing the ultimate elongation (λm) of the gels. We reveal that this enhancement of λm due to the slidable crosslinks is pronounced specifically in uniaxial stretching while it is considerably modest in biaxial stretching. The sensitivity of λm to loading axiality becomes larger as the ring densities decreases. The corresponding difference in λm is markedly larger for the PR gels with low ring densities than that for the networks with fixed crosslinks. The exceptional sensitivity of λm to loading axiality unveils a previously unidentified aspect of the chain-supply mechanism based on slidable crosslinks. The results came from multiple reactions, including the reaction of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Formula: C12H22F6N6OP2)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.Formula: C12H22F6N6OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Product Details of 56602-33-6In 2018 ,《Designing interactions by control of protein-ligand complex conformation: tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions》 appeared in Chemical Science. The author of the article were Noresson, A.-L.; Aurelius, O.; Oeberg, C. T.; Engstroem, O.; Sundin, A. P.; Haakansson, M.; Stenstroem, O.; Akke, M.; Logan, D. T.; Leffler, H.; Nilsson, U. J.. The article conveys some information:

We investigated galectin-3 binding to 3-benzamido-2-O-sulfo-galactoside and -thiodigalactoside ligands using a combination of site-specific mutagenesis, X-ray crystallog., computational approaches, and binding thermodn. measurements. The results reveal a conformational variability in a surface-exposed arginine (R144) side chain in response to different aromatic C3-substituents of bound galactoside-based ligands. Fluorinated C3-benzamido substituents induced a shift in the side-chain conformation of R144 to allow for an entropically favored electrostatic interaction between its guanidine group and the 2-O-sulfate of the ligand. By contrast, binding of ligands with non-fluorinated substituents did not trigger a conformational change of R144. Hence, a sulfate-arginine electrostatic interaction can be tuned by the choice of ligand C3-benzamido structures to favor specific interaction modes and geometries. These results have important general implications for ligand design, as the proper choice of arginine-aromatic interacting partners opens up for ligand-controlled protein conformation that in turn may be systematically exploited in ligand design. After reading the article, we found that the author used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Product Details of 56602-33-6)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Product Details of 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《High-yield synthesis of oligoribonucleotides using o-nitrobenzyl protection of 2′-hydroxyls》 was written by Hayes, J. A.; Brunden, M. J.; Gilham, P. T.; Gough, G. R.. Application In Synthesis of 3-Nitro-1-tosyl-1H-1,2,4-triazole And the article was included in Tetrahedron Letters in 1985. The article conveys some information:

Use of published procedures for photolytic removal of 2′-O-(o-nitrobenzyl) substituents from model oligoribonucleotides results in low yields of fully-deprotected products accompanied by significant amounts of oligomers carrying altered, UV light-resistant residues derived from the 2′-blocking groups. The efficiency of the deprotection has depends on pH; the side-reactions are avoided when the photolysis is carried out in solution buffered at pH 3.5. In the experiment, the researchers used many compounds, for example, 3-Nitro-1-tosyl-1H-1,2,4-triazole(cas: 77451-51-5Application In Synthesis of 3-Nitro-1-tosyl-1H-1,2,4-triazole)

3-Nitro-1-tosyl-1H-1,2,4-triazole(cas: 77451-51-5) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application In Synthesis of 3-Nitro-1-tosyl-1H-1,2,4-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics