Month: October 2022

SDS of cas: 56602-33-6In 2019 ,《Copper(II) Acetate Mediated Synthesis of 3-Sulfonyl-2-aryl-2H-chromenes》 was published in Synthesis. The article was written by Chang, Meng-Yang; Chen, Yu-Hsin; Chen, Han-Yu. The article contains the following contents:

This paper describes a concise, easy-operation, high-yielding method for the synthesis of 3-sulfonyl-2-aryl-2H-chromenes I [R = Me, n-Bu, 4-H3CC6H4, etc.; R1 = H; R2 = H, OCH3; R1R2 = -CH=CH-CH=CH-; R3 = H, Cl, Br; Ar = 2-furyl, 2-naphthyl, 3,4,5-(H3CO)3C6H2, etc.] by a one-pot, straightforward two-step synthetic route, which includes (i) Cu(OAc)2/PyBOP-mediated intermol. [4+2] annulation of substituted salicylic acids 2-OH-3-R1-4-R2-5-R3C6HC(O)OH with β-sulfonylstyrenes ArCH=CHS(O)2R in the presence of DMAP in refluxing DMF, and (ii) sequential O-alkylation of the resulting sulfonylflavanones II with Bu bromide. A plausible mechanism is proposed and discussed. This protocol provides a highly effective annulation via one carbon-oxygen (C-O) and one carbon-carbon (C-C) bond formations. After reading the article, we found that the author used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6SDS of cas: 56602-33-6)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.SDS of cas: 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《Nonpyrolyzed Fe-N Coordination-Based Iron Triazolate Framework: An Efficient and Stable Electrocatalyst for Oxygen Reduction Reaction》 were Huang, Zheng-Hong; Xie, Nan-Hong; Zhang, Min; Xu, Bo-Qing. And the article was published in ChemSusChem in 2019. Product Details of 288-36-8 The author mentioned the following in the article:

Pyrolyzed base-metal-based metal-organic frameworks (MOFs) with FeNx coordination are emerging as nonprecious metal catalysts for electrochem. oxygen reduction reaction (ORR). However, surprisingly, nonpyrolyzed MOFs involving Fe-N coordination have not been explored for the ORR. This study concerns the catalytic performance of a semiconducting nonpyrolyzed iron triazolate framework (FeTa2) for ORR in alk. electrolyte. The FeTa2 catalyst is studied as composites with different amounts of conductive Ketjenblack carbon (KB). The performance of these FeTa2-x KB (x denotes the KB/FeTa2 weight ratio) composites by onset and half-wave potentials of ORR appears to be superior to most previously documented nonpyrolyzed MOFs. Characterization by elemental anal., FTIR spectroscopy, XPS, and cyclic voltammetry suggest that N-FeIII-OH- sites at the surface of FeTa2 function as the catalytic active sites. This FeTa2 also shows very stable activity during ORR, as supported by accelerated durability test of the FeTa2-x KB sample (20 000 cycles, ca. 90 h). The framework structure of FeTa2 remains intact during the durability test, which would help to explain its excellent catalytic durability. This would be the first study demonstrating efficient and stable ORR catalysis by a nonpyrolyzed Fe-N coordination-based MOF material. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8Product Details of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Product Details of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Cu-Catalyzed Site-Selective and Enantioselective Ring Opening of Cyclic Diaryliodoniums with 1,2,3-Triazoles》 was published in Organic Letters in 2020. These research results belong to Chao, Zengyin; Ma, Mingming; Gu, Zhenhua. Recommanded Product: 288-36-8 The article mentions the following:

A Cu-catalyzed enantioselective ring-opening/triazolylation reaction is reported. The reaction shows excellent chemoselectivity regarding the three different nitrogen atoms of 1,2,3-triazoles. The optically enriched axially chiral aryl iodides thus obtained were readily derivatized to different types of chiral phosphine ligands and their corresponding copper or palladium complexes. In the experimental materials used by the author, we found 1H-1,2,3-Triazole(cas: 288-36-8Recommanded Product: 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Recommanded Product: 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Azido-Enolonium Species in C-C and C-N Bond-Forming Coupling Reactions》 was written by More, Atul A.; Santra, Sourav K.; Szpilman, Alex M.. Electric Literature of C2H3N3 And the article was included in Organic Letters in 2020. The article conveys some information:

Vinyl azides react with boron trifluoride activated Koser’s hypervalent iodine reagent to afford azido-enolonium species. These previously unknown azido-enolonium species react efficiently with aromatic compounds, allyltrimethylsilane, and azoles under mild conditions, with no need for a transition-metal catalyst, forming C-C and C-N bonds to give a variety of α-functionalized ketones. The intermediacy of the proposed azido-enolonium species is supported by spectroscopic studies.1H-1,2,3-Triazole(cas: 288-36-8Electric Literature of C2H3N3) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Electric Literature of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2022,Kitaoka, Satoshi; Nishinaka, Shinnosuke; Nobuoka, Kaoru published an article in Heterocycles. The title of the article was 《Substituent effects on physical properties of azole based ionic liquids》.Application In Synthesis of 1H-1,2,3-Triazole The author mentioned the following in the article:

The effect of the substituents on the phys. properties of azole based ionic liquids, such as m.p. and viscosity is investigated. The introduction of electron-withdrawing groups to azolate anions and electron-donating groups to azolium cations delocalized the charge of anion or cation, and reduced the viscosity and m.p. of the ionic liquids The charge of the azolium cations and the azolate anions are distributed not only on the azole ring but also on the substituents. The decrease in the charge d. of anions and cations in ionic liquids weakens the interaction between the anions and the cations, resulting in a decrease in the viscosity of the ionic liquids Such a method of delocalizing the anion and cation charges of triazole-based ionic liquids by introduction of the substituents can be applied to reduce the viscosity of various ionic liquids as reaction medium and electrolytes. In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8Application In Synthesis of 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application In Synthesis of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2017,Ozdemir, Tugba; Lu, Yu-Chen; Kolemen, Safacan; Tanriverdi-Ecik, Esra; Akkaya, Engin U. published 《Generation of Singlet Oxygen by Persistent Luminescent Nanoparticle-Photosensitizer Conjugates: A Proof of Principle for Photodynamic Therapy without Light》.ChemPhotoChem published the findings.Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V) The information in the text is summarized as follows:

The broader application of photodynamic therapy as a treatment procedure for cancer is hampered by the limited penetration of light through mammalian tissues. Since the photosensitized generation of cytotoxic singlet oxygen requires effective excitation of the tumor-localized photosensitizer, photodynamic action can only be guaranteed for the first few millimeters of the irradiated tissues. In this work, we demonstrated that the phenomenon of persistent luminescence, i.e., delayed emission from certain metal-ion excited states (with crystal defects acting as energy traps), can provide an alternative excitation possibility. Thus, persistent luminescent nanoparticles functionalized by FRET-matching Bodipy sensitizers (FRET=Foerster resonance energy transfer) were excited in situ before administration into a cell culture or an organism. It was found that this system continues to produce singlet oxygen regardless of their location and without any need for continuous photonic excitation. In the part of experimental materials, we found many familiar compounds, such as ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V))

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Huang, Rong; Li, Zhihong; Sheng, Yao; Yu, Jianghui; Wu, Yue; Zhan, Yuexiong; Chen, Hongli; Jiang, Biao published 《N-Methyl-N-phenylvinylsulfonamides for Cysteine-Selective Conjugation》.Organic Letters published the findings.Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The information in the text is summarized as follows:

Use of N-methyl-N-phenylvinylsulfonamides to perform chemoselective modification of cysteine-containing peptides and proteins is reported. Probes linked to the drug were applicable to prepare antibody-drug conjugates (ADCs). The drug-antibody ratio for ADCs was controlled by rationally tuning the electron deficiency and linker hydrophilicity of the probes. In the experimental materials used by the author, we found Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)aminePolytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Mishra, Vandana; Rathore, Ishan; Arekar, Anagha; Sthanam, Lakshmi Kavitha; Xiao, Huogen; Kiso, Yoshiaki; Sen, Shamik; Patankar, Swati; Gustchina, Alla; Hidaka, Koushi; Wlodawer, Alexander; Yada, Rickey Y.; Bhaumik, Prasenjit published 《Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins – biochemical and structural insights》.FEBS Journal published the findings.Product Details of 56602-33-6 The information in the text is summarized as follows:

Malaria is a deadly disease killing worldwide hundreds of thousands people each year and the responsible parasite has acquired resistance to the available drug combinations. The four vacuolar plasmepsins (PMs) in Plasmodium falciparum involved in Hb (Hb) catabolism represent promising targets to combat drug resistance. High antimalarial activities can be achieved by developing a single drug that would simultaneously target all the vacuolar PMs. We have demonstrated for the first time the use of soluble recombinant plasmepsin II (PMII) for structure-guided drug discovery with KNI inhibitors. Compounds used in this study (KNI-10742, 10743, 10395, 10333, and 10343) exhibit nanomolar inhibition against PMII and are also effective in blocking the activities of PMI and PMIV with the low nanomolar Ki values. The high-resolution crystal structures of PMII-KNI inhibitor complexes reveal interesting features modulating their differential potency. Important individual characteristics of the inhibitors and their importance for potency have been established. The alkylamino analog, KNI-10743, shows intrinsic flexibility at the P2 position that potentiates its interactions with Asp132, Leu133, and Ser134. The phenylacetyl tripeptides, KNI-10333 and KNI-10343, accommodate different ρ-substituents at the P3 phenylacetyl ring that determine the orientation of the ring, thus creating novel hydrogen-bonding contacts. KNI-10743 and KNI-10333 possess significant antimalarial activity, block Hb degradation inside the food vacuole, and show no cytotoxicity on human cells; thus, they can be considered as promising candidates for further optimization. Based on our structural data, novel KNI derivatives with improved antimalarial activity could be designed for potential clin. use. Database : Structural data are available in the PDB under the accession numbers 5YIE, 5YIB, 5YID, 5YIC, and 5YIA. The experimental process involved the reaction of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Product Details of 56602-33-6)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.Product Details of 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Wang, Jing-Hao; Lei, Tao; Nan, Xiao-Lei; Wu, Hao-Lin; Li, Xu-Bing; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu. Recommanded Product: 1H-1,2,3-Triazole. The article was titled 《Regioselective Ortho Amination of an Aromatic C-H Bond by Trifluoroacetic Acid via Electrochemistry》. The information in the text is summarized as follows:

Aryl ethers such as anisole underwent regioselective electrochem. ortho-amination/arylation with pyrazoles and aromatic nitrogen heterocycles mediated by trifluoroacetic acid (TFA) in an undivided cell to give arylpyrazoles such as 1-(2-methoxyphenyl)pyrazole and arylated nitrogen heterocycles. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Recommanded Product: 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Recommanded Product: 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,RSC Advances included an article by Peterson, Anna; Kaasik, Mikk; Metsala, Andrus; Jarving, Ivar; Adamson, Jasper; Kanger, Tonis. Formula: C30H30N10. The article was titled 《Tunable chiral triazole-based halogen bond donors: assessment of donor strength in solution with nitrogen-containing acceptors》. The information in the text is summarized as follows:

Strong halogen bond (XB) donors were needed for the activation of neutral substrates. It was demonstrated that XB donor properties of iodo-triazoles could be significantly enhanced by quaternization in combination with varying the counterion and aromatic substituent, exemplified by association constants with quinuclidine as high as 1.1 × 104 M-1. In the experiment, the researchers used many compounds, for example, Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Formula: C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Formula: C30H30N10Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics