Day: October 20, 2022

《Two ways of spin crossover in an iron(II) coordination polymer associated with conformational changes of a bridging ligand》 was published in Dalton Transactions in 2020. These research results belong to Ksiazek, Maria; Weselski, Marek; Dreczko, Agnieszka; Maliuzhenko, Vladyslav; Kazmierczak, Marcin; Toloczko, Aleksandra; Kusz, Joachim; Bronisz, Robert. Name: 1H-1,2,3-Triazole The article mentions the following:

1,4-Di(1-ethyl-1,2,3-triazol-5-yl)butane (bbtre) was prepared by lithiation of 1-ethyl-1,2,3-triazole, followed by alkylation with 1,4-dibromobutane. The ligand bbtre forms a three-dimensional network with Fe(II), [Fe(bbtre)3](ClO4)2·2CH3CN, that exhibits thermally induced spin crossover (SCO). A change of temperature or change of spin state results in various types of structural transformation, leading to different structures that are stable in strictly defined temperature ranges. As a result, there are three spin crossover transitions arranged via two different paths. Thus, cooling <280 K involves a HT(HS) → LT(HS) (HT, high temperature structure; LT, low temperature structure; HS, high spin) phase transition (PT), which is associated with conformational changes of the bbtre mols. and with deformation of the polymeric skeleton. In the LT phase incomplete and reversible LT(HS) ⇄ LT(HS/LS) spin crossover occurs (LS, low spin). In contrast, rapid cooling (of a sample not previously thermally treated) allows the HT(HS) → LT(HS) phase transition to be avoided, and so complete HT(HS) → HT1(LS) SCO occurs. This means that the PT plays the role of a switch, which allows a choice of one of two ways in which the SCO will proceed. After rapid cooling, further heating to 150 K and subsequent cooling results in a reversible HT1(HS) ⇄ HT1(LS) spin crossover (T↓1/2 = 130 K, T↑1/2 = 131 K). However, raising the temperature to 170-200 K gives a modulated structure HT2(HS) exhibiting the next reversible HT2(HS) ⇄ HT2(LS) SCO (T↓1/2 = 121 K, T↑1/2 = 123 K). Finally, heating >200 K involves the HT2(HS) → LT(HS) PT and results in a LT(HS) structure exhibiting incomplete LT(HS) ⇄ LT(HS/LS) spin crossover. In the experimental materials used by the author, we found 1H-1,2,3-Triazole(cas: 288-36-8Name: 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Name: 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Cooperative Large-Hysteresis Spin-Crossover Transition in the Iron(II) Triazolate [Fe(ta)2] Metal-Organic Framework》 was written by Grzywa, Maciej; Roess-Ohlenroth, Richard; Muschielok, Christoph; Oberhofer, Harald; Blachowski, Artur; Zukrowski, Jan; Vieweg, Dana; von Nidda, Hans-Albrecht Krug; Volkmer, Dirk. Product Details of 288-36-8 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

The metal-organic framework [Fe(ta)2] (Hta = 1H-1,2,3-triazole) containing Fe(II) ions and 1,2,3-triazolate ligands shows a reversible phase transition while retaining the cubic crystal symmetry and space group Fd3m. The phase transition between room temperature (RT-[Fe(ta)2]; a 16.6315(2) Å, V = 4600.39(8) Å3) and high temperature (HT-[Fe(ta)2]; a 17.7566(4) Å, V = 5598.6(1) Å3) phases occurs at a temperature >290°, whereas the phase transition between HT- and RT-[Fe(ta)2] starts at a temperature <210°. Both [Fe(ta)2] polymorphs have identical bond topologies, but they differ by a large increase of the unit cell's volume of 22% for HT-[Fe(ta)2]. The compounds were characterized by powder x-ray diffraction, DSC, and thermogravimetric analyses. Addnl., Mossbauer spectroscopy, magnetic studies, and the electronic structure of both phases are discussed in detail with respect to the spin-crossover transition from the low-spin (RT-[Fe(ta)2]) to the high-spin phase (HT-[Fe(ta)2]). The metal-organic framework [Fe(ta)2] (Hta = 1H-1,2,3-triazole) shows a reversible coordinative wide-hysteresis phase transition >290° without change of the cubic crystal system and space group. A large difference in the unit cell lengths is observed between the low-spin RT-[Fe(ta)2] (a 16.6315(2) Å, V = 4600.39(8) Å3) and high-spin HT-[Fe(ta)2] (a 17.7566(4) Å, V = 5598.6(1) Å3) phases, which were studied in detail by Mossbauer spectroscopy, DSC, and VT-PXRD. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8Product Details of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Product Details of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2022,Aoyama, Takuma; Kato, Kazuaki; Urayama, Kenji published an article in ACS Macro Letters. The title of the article was 《Marked Sensitivity of Ultimate Elongation to Loading Axiality in Polyrotaxane Gels with Largely Slidable Cross Links》.Formula: C12H22F6N6OP2 The author mentioned the following in the article:

Polyrotaxane (PR) gels with low ring densities have figure-of-eight crosslinks that can slide along network strands. The slidable crosslinks have a unique ability to increase the network strand length between adjacent crosslinks in the loading direction via chain supply from the stress-free direction, thereby enhancing the ultimate elongation (λm) of the gels. We reveal that this enhancement of λm due to the slidable crosslinks is pronounced specifically in uniaxial stretching while it is considerably modest in biaxial stretching. The sensitivity of λm to loading axiality becomes larger as the ring densities decreases. The corresponding difference in λm is markedly larger for the PR gels with low ring densities than that for the networks with fixed crosslinks. The exceptional sensitivity of λm to loading axiality unveils a previously unidentified aspect of the chain-supply mechanism based on slidable crosslinks. The results came from multiple reactions, including the reaction of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Formula: C12H22F6N6OP2)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.Formula: C12H22F6N6OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Product Details of 56602-33-6In 2018 ,《Designing interactions by control of protein-ligand complex conformation: tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions》 appeared in Chemical Science. The author of the article were Noresson, A.-L.; Aurelius, O.; Oeberg, C. T.; Engstroem, O.; Sundin, A. P.; Haakansson, M.; Stenstroem, O.; Akke, M.; Logan, D. T.; Leffler, H.; Nilsson, U. J.. The article conveys some information:

We investigated galectin-3 binding to 3-benzamido-2-O-sulfo-galactoside and -thiodigalactoside ligands using a combination of site-specific mutagenesis, X-ray crystallog., computational approaches, and binding thermodn. measurements. The results reveal a conformational variability in a surface-exposed arginine (R144) side chain in response to different aromatic C3-substituents of bound galactoside-based ligands. Fluorinated C3-benzamido substituents induced a shift in the side-chain conformation of R144 to allow for an entropically favored electrostatic interaction between its guanidine group and the 2-O-sulfate of the ligand. By contrast, binding of ligands with non-fluorinated substituents did not trigger a conformational change of R144. Hence, a sulfate-arginine electrostatic interaction can be tuned by the choice of ligand C3-benzamido structures to favor specific interaction modes and geometries. These results have important general implications for ligand design, as the proper choice of arginine-aromatic interacting partners opens up for ligand-controlled protein conformation that in turn may be systematically exploited in ligand design. After reading the article, we found that the author used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Product Details of 56602-33-6)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Product Details of 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《High-yield synthesis of oligoribonucleotides using o-nitrobenzyl protection of 2′-hydroxyls》 was written by Hayes, J. A.; Brunden, M. J.; Gilham, P. T.; Gough, G. R.. Application In Synthesis of 3-Nitro-1-tosyl-1H-1,2,4-triazole And the article was included in Tetrahedron Letters in 1985. The article conveys some information:

Use of published procedures for photolytic removal of 2′-O-(o-nitrobenzyl) substituents from model oligoribonucleotides results in low yields of fully-deprotected products accompanied by significant amounts of oligomers carrying altered, UV light-resistant residues derived from the 2′-blocking groups. The efficiency of the deprotection has depends on pH; the side-reactions are avoided when the photolysis is carried out in solution buffered at pH 3.5. In the experiment, the researchers used many compounds, for example, 3-Nitro-1-tosyl-1H-1,2,4-triazole(cas: 77451-51-5Application In Synthesis of 3-Nitro-1-tosyl-1H-1,2,4-triazole)

3-Nitro-1-tosyl-1H-1,2,4-triazole(cas: 77451-51-5) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application In Synthesis of 3-Nitro-1-tosyl-1H-1,2,4-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA》 was written by Kour, Smit; Rana, Sandeep; Kizhake, Smitha; Lagundzin, Dragana; Klinkebiel, David; Mallareddy, Jayapal Reddy; Huxford, Tom; Woods, Nicholas T.; Natarajan, Amarnath. Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amineThis research focused ontumor necrosis factor alpha stapling protein RELA nuclear translocation. The article conveys some information:

Tumor necrosis factor (TNF) α-induced nuclear translocation of the NF-ΚB subunit RELA has been implicated in several pathol. conditions. Here we report the discovery of a spirocyclic dimer (SpiD7) that covalently modifies RELA to inhibit TNFα-induced nuclear translocation. This is a previously unexplored strategy to inhibit TNFα-induced NF-ΚB activation. The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,Dalton Transactions included an article by Tran, Thi V.; Couture, Garret; Do, Loi H.. SDS of cas: 510758-28-8. The article was titled 《Evaluation of dicopper azacryptand complexes in aqueous CuAAC reactions and their tolerance toward biological thiols》. The information in the text is summarized as follows:

Dicopper azacryptand complexes were evaluated in Cu-catalyzed azide-alkyne cycloaddition (CuAAC) in H2O at 37°. They showed high activity at concentrations ≥5 μM. These dinuclear catalysts were more susceptible toward inhibition by cysteine rather than glutathione under the conditions tested. The mononuclear Cu complexes that are ligated by tripodal amine ligands, also exhibited good catalytic activity in aqueous media and showed similar sensitivity toward biol. thiols as that of the dinuclear complexes. The results suggest that the azacryptand catalysts are too structurally flexible to adequately prevent interactions of their metal centers with external nucleophiles. However, further steric tuning of the ligand structure might enable more effective substrate gating in future studies. The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8SDS of cas: 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.SDS of cas: 510758-28-8Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《Triazolyl C-nucleosides via the intermediacy of β-1′-ethynyl-2′-deoxyribose derived from a Nicholas reaction: Synthesis, photophysical properties and interaction with BSA》 were Bag, Subhendu Sekhar; Das, Suman Kalyan. And the article was published in Tetrahedron in 2019. Synthetic Route of C30H30N10 The author mentioned the following in the article:

We report the design and synthesis of triazolyl donor/acceptor unnatural C-nucleosides via alkyne (sugar)-azide (aromatic) 1, 3-dipolar cycloaddition reaction as a key step and studies on their photophys. properties. We have chosen β-1′-ethynyl-2′-deoxyribose as a precursor to synthesize triazolyl-C-nucleosides. Overcoming the difficulties, we obtain β-1′-ethynyl-2′-deoxyribose as a major product following a Co2(CO)8 catalyzed intramol. Nicholas reaction. The 1,3-diaxial interaction is the driving force for the α to β-anomeric conversion while performing cobalt complexation followed by oxidation to afford β-1′- ethynyl-2′-deoxyribose as the major product. A Cu(I)-catalyzed click reaction between different aromatic donor/acceptor azides and β-1′- ethynyl-2′-deoxyribose generates the desired unnatural triazolyl donor-acceptor aromatic C-nucleosides (cTBDo/Ac) within 30 min. Single crystal X-ray structure shows the puckered conformation of sugar as C3′-exo. Studies on the photophys. properties suggests good fluorophoric as well as solvatochromic characteristics of these nucleosides. Two of the synthesized nucleosides, cTAnthBDo and cTPyBDo, are found to interact with BSA as the only tested protein with quenching of fluorescence signal. The designed bases, thus, might find applications in stabilizing a DNA and in the biophys. study thereof, if a pair of such donor acceptor C-nucleosides could be incorporated into a DNA sequence. After reading the article, we found that the author used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Synthetic Route of C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Synthetic Route of C30H30N10

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《Triazole Ureas Covalently Bind to Strigolactone Receptor and Antagonize Strigolactone Responses》 were Nakamura, Hidemitsu; Hirabayashi, Kei; Miyakawa, Takuya; Kikuzato, Ko; Hu, Wenqian; Xu, Yuqun; Jiang, Kai; Takahashi, Ikuo; Niiyama, Ruri; Dohmae, Naoshi; Tanokura, Masaru; Asami, Tadao. And the article was published in Molecular Plant in 2019. Application In Synthesis of 1H-1,2,3-Triazole The author mentioned the following in the article:

Strigolactones, a class of plant hormones with multiple functions, mediate plant-plant and plant-microorganism communications in the rhizosphere. In this study, we developed potent strigolactone antagonists, which covalently bind to the strigolactone receptor D14, by preparing an array of triazole urea compounds Using yeast two-hybrid and rice-tillering assays, we identified a triazole urea compound KK094 as a potent inhibitor of strigolactone receptors. Liquid chromatog.-tandem mass spectrometry anal. and X-ray crystallog. revealed that KK094 was hydrolyzed by D14, and that a reaction product of this degradation covalently binds to the Ser residue of the catalytic triad of D14. Furthermore, we identified two triazole urea compounds KK052 and KK073, whose effects on D14-D53/D14-SLR1 complex formation were opposite due to the absence (KK052) or presence (KK073) of a trifluoromethyl group on their Ph ring. These results demonstrate that triazole urea compounds are potentially powerful tools for agricultural application and may be useful for the elucidation of the complicated mechanism underlying strigolactone perception. After reading the article, we found that the author used 1H-1,2,3-Triazole(cas: 288-36-8Application In Synthesis of 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application In Synthesis of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Kang, Tae Woong; Tamura, Atsushi; Arisaka, Yoshinori; Yui, Nobuhiko published their research in Polymer Chemistry in 2021. The article was titled 《Visible light-degradable supramolecular gels comprising cross-linked polyrotaxanes capped with trithiocarbonate groups》.Recommanded Product: ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V) The article contains the following contents:

Visible light-degradable supramol. gels were designed using polyrotaxanes (PRXs) containing bulky trithiocarbonate groups as stopper mols. that are cleaved by visible light irradiation Visible-light-degradable PRXs comprise poly(ethylene glycol) (PEG) threaded through multiple α-cyclodextrins, where both terminals of the PEG axis were capped with bulky trithiocarbonate groups. The synthesized PRXs did not degrade in the dark. Irradiation with UV (UV; 365 nm, 7.03 mW cm-2) and visible light (465 nm, 44.5 mW cm-2) induced cleavage of the trithiocarbonate groups, and the α-cyclodextrins were dethreaded from the axial chain, demonstrating the photodegradability of PRXs capped with trithiocarbonate groups. Visible light-degradable supramol. gels were prepared by crosslinking PRXs with hexamethylene diisocyanate. The supramol. gels were degraded and disappeared upon irradiation with both UV and visible light due to photodegradation of PRXs. Visible light degradable supramol. gels are considered to be a new type of photodegradable material that can circumvent the potential phototoxicity of UV light to be applicable for alternative photodegradable biomaterials. The experimental process involved the reaction of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Recommanded Product: ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V))

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.Recommanded Product: ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics