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COA of Formula: C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

COA of Formula: C2H4N4. In 2020.0 CHEMOSPHERE published article about DISSOLVED ORGANIC-MATTER; MOLECULAR-OXYGEN; PHOTOLYSIS; DEGRADATION; PESTICIDES; MECHANISM; ATRAZINE; STATE in [Pozdnyakov, Ivan P.] Novosibirsk State Univ, Novosibirsk 630090, Russia; [Pozdnyakov, Ivan P.] VV Voevodsky Inst Chem Kinet & Combust, Novosibirsk 630090, Russia; [Parkhats, Marina, V] Natl Acad Sci Belarus, BI Stepanov Inst Phys, Minsk 220072, BELARUS in 2020.0, Cited 15.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Reactivity of the singlet oxygen (SO), which is assumed to be one of the important oxidizers in natural waters, towards to a set of persistent herbicides, was measured for the first time using time resolved luminescence technique. It was observed that rate constants of SO reactions with the majority of studied herbicides are less than 10(6) M(-1)s(-1) allowing to conclude about negligible participation of SO in oxidation of the compounds in natural waters. (C) 2020 Elsevier Ltd. All rights reserved.

COA of Formula: C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New explortion of 61-82-5

Recommanded Product: 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Pawlik, A; Ruminowicz-Stefaniuk, M; Frac, M; Mazur, A; Wielbo, J; Janusz, G or send Email.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. In 2019.0 PLOS ONE published article about CELLOBIOSE DEHYDROGENASE; PHENOTYPE MICROARRAYS; BROWN-ROT; DEGRADATION; LACCASE; DIVERSITY; MECHANISMS; ENZYMES in [Pawlik, Anna; Ruminowicz-Stefaniuk, Marta; Janusz, Grzegorz] Marie Curie Sklodowska Univ, Dept Biochem, Lublin, Poland; [Frac, Magdalena] Polish Acad Sci, Inst Agrophys, Lublin, Poland; [Mazur, Andrzej; Wielbo, Jerzy] Marie Curie Sklodowska Univ, Dept Genet & Microbiol, Lublin, Poland in 2019.0, Cited 47.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Cerrena unicolor is a wood-degrading basidiomycete with ecological and biotechnological importance. Comprehensive Biolog-based analysis was performed to assess the metabolic capabilities and sensitivity to chemicals of C. unicolor FCL139 growing in various sawdust substrates and light conditions. The metabolic preferences of the fungus towards utilization of specific substrates were shown to be correlated with the sawdust medium applied for fungus growth and the light conditions. The highest catabolic activity of C. unicolor was observed after fungus precultivation on birch and ash sawdust media. The fungus growing in the dark showed the highest metabolic activity which was indicated by capacity to utilize a broad spectrum of compounds and the decomposition of 74/95 of the carbon sources. In all the culture light conditions, p-hydroxyphenylacetic acid was the most readily metabolized compound. The greatest tolerance to chemicals was also observed during C. unicolor growth in darkness. The fungus was the most sensitive to nitrogen compounds and antibiotics, but more resistant to chelators. Comparative analysis of C. unicolor and selected wood-decay fungi from different taxonomic and ecological groups revealed average catabolic activity of the fungus. However, C. unicolor showed outstanding capabilities to catabolize salicin and arbutin. The obtained picture of C. unicolor metabolism showed that the fungus abilities to decompose woody plant material are influenced by various environmental factors.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Pawlik, A; Ruminowicz-Stefaniuk, M; Frac, M; Mazur, A; Wielbo, J; Janusz, G or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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Product Details of 61-82-5. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

An article Cobalt oxide on mesoporous carbon nitride for improved photocatalytic hydrogen production under visible light irradiation WOS:000476964900044 published article about HETEROJUNCTION PHOTOCATALYSTS; COMPOSITE; WATER; DEGRADATION; NANOTUBES; EVOLUTION; SEMICONDUCTORS; OXIDATION; REDUCTION; PHENOL in [Kheradmand, Anianj; Zhu, Yuxiang; Zhang, Wenwen; Marianov, Aleksei; Jiang, Yijiao] Macquarie Univ, Sch Engn, Sydney, NSW 2109, Australia in 2019.0, Cited 56.0. Product Details of 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Cobalt oxide (Co3O4) nanoparticles decorated on mesoporous carbon nitride (Co3O4/MCN) nanocomposites for photocatalytic hydrogen evolution were investigated in this work. MCN was prepared using 3-amino-1,2,4-triazole, high nitrogen content, as a single molecular carbon and nitrogen precursor and SiO2 nanoparticles as the hard template. Complementary characterization techniques were employed to understand the textural and chemical properties of the nanocomposites. The bare MCN showed high photocatalytic activity under visible light irradiation without using any co-catalyst. The photocatalytic activity of Co3O4/MCN with a Co3O4 mass content of 5 wt % presented two times higher than the bare MCN, which is attributed to the enhanced visible-light harvesting and more efficient charge separation. Mechanistic study shows lower electron-hole recombination rate, higher charge separation efficiency occurs after the formation of p-n type heterojunction. (C) 2019 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.

Product Details of 61-82-5. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Why Are Children Getting Addicted To 1H-1,2,4-Triazol-5-amine

Computed Properties of C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Computed Properties of C2H4N4. In 2020.0 CARBOHYD POLYM published article about CHITOSAN DERIVATIVES; IN-VITRO in [Zhang, Jingjing; Sun, Xueqi; Chen, Yuan; Mi, Yingqi; Tan, Wenqiang; Miao, Qin; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Zhang, Jingjing; Sun, Xueqi; Chen, Yuan; Mi, Yingqi; Tan, Wenqiang; Miao, Qin; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China; [Zhang, Jingjing; Sun, Xueqi; Chen, Yuan; Mi, Yingqi; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China in 2020.0, Cited 47.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

In this study, 2-urea-chitosan oligosaccharide derivatives (2-urea-COS derivatives) and 2,6-diurea-chitosan oligosaccharide derivatives (2,6-diurea-COS derivatives) were successfully designed and synthesized via intermediate 2-methoxyformylated chitosan oligosaccharide. All samples were characterized and compared based on FT-IR, H-1 NMR spectroscopy, and elemental analysis. The antifungal effects of COS derivatives were tested against Fusarium oxysporum f. sp. niveum, Phomopsis asparagus, and Botrytis cinereal. Their antioxidant properties, including superoxide radicals’ scavenging activity, hydroxyl radicals’ scavenging activity, and DPPH radicals’ scavenging activity were also explored within different concentrations. COS derivatives bearing urea groups showed improved bioactivity compared with pristine COS and 2,6-diurea-COS derivatives had a higher biological activity than 2-urea-COS derivatives in tested concentrations. Additionally, L929 cells were used to carry out cytotoxicity test of COS and COS derivatives by CCK-8 assay. The results indicated that some of samples showed low cytotoxicity. These findings offered a suggestion that COS derivatives bearing urea groups are promising biological materials.

Computed Properties of C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Search for chemical structures by a sketch :C2H4N4

Welcome to talk about 61-82-5, If you have any questions, you can contact Grilo, LF; Martins, JD; Cavallaro, CH; Nathanielsz, PW; Oliveira, PJ; Pereira, SP or send Email.. Computed Properties of C2H4N4

Computed Properties of C2H4N4. Grilo, LF; Martins, JD; Cavallaro, CH; Nathanielsz, PW; Oliveira, PJ; Pereira, SP in [Grilo, Luis F.; Martins, Joao D.; Cavallaro, Chiara H.; Oliveira, Paulo J.; Pereira, Susana P.] CNC Ctr Neurosci & Cell Biol, UC Biotech Bldg,Biocant Pk, Cantanhede, Portugal; [Nathanielsz, Peter W.] Coll Agr & Nat Resources, Dept Anim Sci, Laramie, WY USA; [Pereira, Susana P.] Univ Porto, Fac Sport, Res Ctr Phys Act Hlth & Leisure CIAFEL, Porto, Portugal published Development of a 96-well based assay for kinetic determination of catalase enzymatic-activity in biological samples in 2020.0, Cited 64.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Oxidative stress biomarkers are powerful endpoints in toxicological research. Cellular reductive/oxidative balance affects numerous signaling pathways involving H2O2. Detoxification and control of H2O2 levels results mainly from catalase activity. The aim of this work was to develop a precise, simple, cost-effective microassay to measure catalase activity in small tissue samples and cell extracts. We developed a protocol that quantifies H2O2 decomposition by intrinsic catalase in biological samples. Catalase activity was calculated based on rate of decomposition of H2O2, following absorbance at 240 nm. We developed a multi-well spectroscopic approach, reducing sample quantity requirements and allowing simultaneous assessment of large number of samples. The protocol is sensitive across a wide range of catalase activity (11.5-7575 U). The assay presents a 95% confidence interval with an intra-assay coefficient of variation of 3.7%, an inter-assay coefficient of variation of 6.2% and good correlation with a commercial kit. The assay was established and validated for different biological samples, including sheep hepatic tissue and human tumor and non-tumor cell lines. This high-throughput method is robust, sensitive, time-saving and cost-effective, generating highly reproducible results with precision and good correlation with a commercial kit reinforcing the method’s validity for research and toxicological applications.

Welcome to talk about 61-82-5, If you have any questions, you can contact Grilo, LF; Martins, JD; Cavallaro, CH; Nathanielsz, PW; Oliveira, PJ; Pereira, SP or send Email.. Computed Properties of C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

What I Wish Everyone Knew About 1H-1,2,4-Triazol-5-amine

Welcome to talk about 61-82-5, If you have any questions, you can contact Sompalle, R; Roopan, SM; Priya, DD; Suthindhiran, K; Sarkar, G; Ranjith, M; Arunachalapandi, M or send Email.. Category: Triazoles

Authors Sompalle, R; Roopan, SM; Priya, DD; Suthindhiran, K; Sarkar, G; Ranjith, M; Arunachalapandi, M in WILEY-V C H VERLAG GMBH published article about CARBOXYLIC-ACID DERIVATIVES; ANTITUMOR AGENTS; ANTIOXIDANT; INHIBITORS; DESIGN; POTENT in [Sompalle, Rajesh; Roopan, Selvaraj Mohana; Priya, Duraipandi Devi; Arunachalapandi, Murugan] Vellore Inst Technol, Sch Adv Sci, Dept Chem, Chem Heterocycles & Nat Prod Res Lab, Vellore 632014, Tamil Nadu, India; [Sompalle, Rajesh] Besant Theosoph Coll, Dept Chem, Chittoor 517325, Andhra Pradesh, India; [Suthindhiran, Krishnamurthy; Sarkar, Gargi] Vellore Inst Technol, Sch Biosci & Technol, Marine Biotechnol & Bioprod Lab, Vellore 632014, Tamil Nadu, India; [Ranjith, Malavika] Vellore Inst Technol, Sch Chem Engn, Vellore 632014, Tamil Nadu, India in 2020.0, Cited 45.0. Category: Triazoles. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Microwave synthetic methodologies were proposed for the preparation of positional isomeric dihydro-triazolo-pyrimido-acridines, 3a-j and 9a-h via friedlander synthesis using response surface methodology (RSM). The advantages of these methodologies over conventional methods are it provides good yields with short reaction times. Free radical scavenging and antifungal studies were performed for compounds 3a-j and 9a-h. The results of antioxidant assay revealed that compounds 3c, 3d and 9b exhibited excellent property whereas compounds 3a and 9a showed significant antifungal property against Aspergillus flavus (A.flavus) and Aspergillus niger (A. niger).

Welcome to talk about 61-82-5, If you have any questions, you can contact Sompalle, R; Roopan, SM; Priya, DD; Suthindhiran, K; Sarkar, G; Ranjith, M; Arunachalapandi, M or send Email.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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An article Effect of Fe3O4-Decorated N-Doped Reduced Graphene Oxide Nanohybrid on the Anticorrosion Performance of Epoxy Composite Coating WOS:000514099500005 published article about FUNCTIONALIZED GRAPHENE; CORROSION PROTECTION; GRAPHITE OXIDE; ENHANCEMENT; RESISTANCE; NANOSHEETS; INHIBITORS; ZIRCONIA; DELIVERY; CATALYST in [Chhetri, Suman; Ghosh, Souvik; Samanta, Pranab; Murmu, Naresh Chandra; Kuila, Tapas] CSIR Cent Mech Enging Res Inst, Surface Engn & Tribol Div, Durgapur 713209, India; [Chhetri, Suman; Ghosh, Souvik; Samanta, Pranab; Murmu, Naresh Chandra; Kuila, Tapas] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2019.0, Cited 41.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. HPLC of Formula: C2H4N4

The present study explores the synergistic effect of Fe3O4 and heteroatom doped reduced graphene oxide (rGO) nanohybrid on anti-corrosion performance of epoxy composite coating. In this connection, Fe3O4 nanoparticles were decorated over nitrogen doped rGO (Fe3O4-NRG) and characterized by Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, X-ray diffraction (XRD), X-ray Photoelectron spectroscopy (XPS), and Thermogravimetric analysis (TGA). This approach to modulating the surface properties of graphene and hence the interaction with polymer matrix were quite distinct from traditional surface functionlization or decoration in a sense that the doped nitrogen atom facilitate the growth of Fe3O4 particles and at the same time augmented the interaction of rGO with polymer matrix. The prepared nanohybrid was dispersed in epoxy matrix through mechanical mixing and coated over mild steel surface via spin coating technique. The potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) study revealed superior anti-corrosion performance of Fe3O4-NRG/epoxy coating in 3.5 wt% NaCl solution. The corrosion inhibition was found to improve by similar to 98.5% with 0.5 wt% loading of Fe3O4-NRG. We believe that this simple solvent free approach to prepare composite coating can be exploit for practical application and thus deserves special attention..

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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Computed Properties of C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Computed Properties of C2H4N4. In 2021.0 NEW J CHEM published article about HIGH-NITROGEN; DERIVATIVES; EXPLOSIVES in [Lu, Tian; He, Yuna; Song, Jia; Hou, Zhengwen; Yin, Hongquan; Chen, Fu-Xue] Beijing Inst Technol, Sch Chem Sc Chem Engn, Liangxiang Campus,8 Liangxiang East Rd, Beijing 102488, Peoples R China; [Fan, Guijuan] CAEP, Inst Chem Mat, Mianyang 621050, Sichuan, Peoples R China in 2021.0, Cited 37.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Eight energetic salts with a gem-dinitro group based on 1,2,4-oxadiazole were developed. All of the structures were confirmed by infrared (IR) spectroscopy, H-1 and C-13 nuclear magnetic resonance (NMR) spectroscopy, and high-resolution mass spectrometry (HRMS), and single-crystal X-ray diffraction was used to determine the structures of the pivotal intermediate 3-(chlorodinitromethyl)-5-methyl-1,2,4-oxadiazole (3), the potassium salt (4) and the hydrazinium salt (7). All of them are insensitive to impact (>40 J) and have higher energy levels than trinitrotoluene (TNT).

Computed Properties of C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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Quality Control of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

An article Toxicological response of the model fungus Saccharomyces cerevisiae to different concentrations of commercial graphene nanoplatelets WOS:000563268400007 published article about WALLED CARBON NANOTUBES; CUO NANOPARTICLES; GENE-EXPRESSION; YEAST; TOXICITY; OXIDE; STRESS; GROWTH; MECHANISMS; PROTEIN in [Suarez-Diez, Maria; Schaap, Peter J.] Wageningen Univ & Res, Lab Syst & Synthet Biol, Stippeneg 4, NL-6708 WE Wageningen, Netherlands; [Porras, Santiago] Univ Burgos, Dept Econ Aplicada, Plaza Infanta Dona Elena S-N, Burgos 09001, Spain; [Laguna-Teno, Felix; Tamayo-Ramos, Juan A.] Univ Burgos, Int Res Ctr Crit Raw Mat ICCRAM, Plaza Misael Banuelos S-N, Burgos 09001, Spain in 2020.0, Cited 92.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Quality Control of 1H-1,2,4-Triazol-5-amine

Graphene nanomaterials have attracted a great interest during the last years for different applications, but their possible impact on different biological systems remains unclear. Here, an assessment to understand the toxicity of commercial polycarboxylate functionalized graphene nanoplatelets (GN) on the unicellular fungal model Saccharomyces cerevisiae was performed. While cell proliferation was not negatively affected even in the presence of 800 mg L-1 of the nanomaterial for 24 hours, oxidative stress was induced at a lower concentration (160 mg L-1), after short exposure periods (2 and 4 hours). No DNA damage was observed under a comet assay analysis under the studied conditions. In addition, to pinpoint the molecular mechanisms behind the early oxidative damage induced by GN and to identify possible toxicity pathways, the transcriptome of S. cerevisiae exposed to 160 and 800 mg L-1 of GN was studied. Both GN concentrations induced expression changes in a common group of genes (337), many of them related to the fungal response to reduce the nanoparticles toxicity and to maintain cell homeostasis. Also, a high number of genes were only differentially expressed in the GN800 condition (3254), indicating that high GN concentrations can induce severe changes in the physiological state of the yeast.

Quality Control of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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Safety of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Recently I am researching about GALETERONE; DEGRADATION; ABIRATERONE; INHIBITION; CHROMATIN; ESTRONE; BINDING; ACCESS, Saw an article supported by the National Research, Development and Innovation OfficeNational Research, Development & Innovation Office (NRDIO) – Hungary [OTKA K124544]; Grant Agency of the Czech RepublicGrant Agency of the Czech Republic [GA20-15621S]; Palacky University Olomouc [IGA_PrF_2021_007]; ELIXIR CZ research infrastructure project (MEYS) [LM2018131]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Kiss, MA; Perina, M; Bazgier, V; May, NV; Baji, A; Jorda, R; Frank, E. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. Category: Triazoles

One of the main directions of steroid research is the preparation of modified derivatives in which, in addition to changes in physicochemical properties, receptor binding is significantly altered, thus a bioactivity different from that of the parent compound predominates. In the frame of this work, 2-arylidene derivatives were first synthesized by regioselective modification of the A-ring of natural sex hormone, 5 alpha-dihydrotestosterone (DHT). After Claisen-Schmidt condensations of DHT with (hetero)aromatic aldehydes in alkaline EtOH, heterocyclizations of the alpha,beta-enones were performed with 3-amino-1,2,4-triazole, 3-aminopyrazole and 3-amino-5-methylpyrazole in the presence of t-BuOK in DMF to afford 7 ‘-epimeric mixtures of A-ring-fused azolo-dihydropyrimidines, respectively. Depending on the electronic demand of the substituents of the arylidene moiety, spontaneous or 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ)-induced oxidation of the heteroring led to triazolo[1,5-a]pyrimidines and pyrazolo[1,5-a]pyrimidines in good yields, while, using the Jones reagent as a strong oxidant, 17oxidation also occurred. The crystal structures of an arylidene and a triazolopyrimidine product have been determined by single crystal X-ray diffraction and both were found to crystallize in the monoclinic crystal system at P21 space group. Most derivatives were found to diminish the transcriptional activity of androgen receptor (AR) in reporter cell line. The candidate compound (17 beta-hydroxy-2-(4-chloro)benzylidene-5 alpha-androstan-3-one, 2f) showed to suppress androgen-mediated AR transactivation in a dose-dependent manner. We confirmed the cellular interaction of 2f with AR, described the binding in AR-binding cavity by the flexible docking and showed the ability of the compound to suppress the expression of AR-regulated genes in two prostate cancer cell lines.

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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics