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Safety of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Wang, X; Ma, B; Wang, YT; Lu, SY; Ma, M; Shi, YQ; Chen, S or send Email.

Wang, X; Ma, B; Wang, YT; Lu, SY; Ma, M; Shi, YQ; Chen, S in [Wang, Xu; Ma, Biao; Wang, Yating; Lu, Songyan; Ma, Meng; Shi, Yanqin; Chen, Si] Zhejiang Univ Technol, Coll Mat Sci & Engn, Hangzhou 310014, Zhejiang, Peoples R China published A new theory of two-step stabilization mechanism for triazole-based zinc-containing complex as thermal stabilizer for polyvinyl chloride) in 2019.0, Cited 31.0. Safety of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

A totally new theory of two-step stabilization mechanism for triazole-based zinc-containing complex (abbreviated as (Zn(ttr)(OAc)]) was proposed through several designed experiments. [Zn(ttr)(OAc)] strongly absorbed HCl at the beginning, and then broke down into 3-amino-1,2,4-triazole which could further stabilized PVC. The structure of [Zn(ttr)(OAc)] was characterized by FTIR spectroscopy, elemental analysis and SEM. Then, Congo red tests and discoloration tests verified [Zn(ttr)(OAc)] could absorb HCl effectively, but PVC showed poor initial whiteness, which further proved above -mentioned stabilization mechanism. Moreover, [Zn(ttr)(OAc)] combined with ZnSt(2) and dibenzoyl methane (DBM) effectively improved the initial color of PVC samples and provided PVC with shorter plasticizing time and longer dynamic thermal stability time than commercial stabilizer 1086F, confirmed by discoloration tests and dynamic thermal stability analysis. We believe [Zn(ttr)(OAc)]/ZnSt(2)/DBM stabilizer system can be used as a commercial stabilizer and the stabilization mechanism of [Zn(ttr)(OAc)] may provide a new way to stabilize PVC. (C) 2019 Published by Elsevier Ltd.

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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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Category: Triazoles. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Category: Triazoles. Recently I am researching about QUANTUM-CHEMICAL CALCULATIONS; CARBONIC-ANHYDRASE-IX; SULFAMETHAZINE SCHIFF-BASE; HUMAN THYMIDYLATE SYNTHASE; DENSITY-FUNCTIONAL THEORY; CRYSTAL-STRUCTURE; ANTIMICROBIAL ACTIVITY; VIBRATIONAL-SPECTRA; BROMOBENZENE DERIVATIVES; SULFONAMIDE DERIVATIVES, Saw an article supported by the . Published in ELSEVIER SCIENCE BV in AMSTERDAM ,Authors: Fahim, AM; Shalaby, MA. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

The reaction of N-(4-acetylphenyl)benzene sulphonamide derivatives 3a and 3b with N,N dimethyl formamide dimethyl acetal (DMF-DMA) afford acryloyl(phenyl)benzenesulfonamide derivatives 4a and 4b; respectively. The chemical reactivity of enaminonitriles 4a and 4b towards hydrazine hydrate or hydroxylamine was studied for synthesizing of pyrazolyl and isoxazolyl-phenyl benzenesulfonamide derivatives 5a,b and 6a,b; respectively. Also, the treatment of enaminonitriles 4a and 4b with thiosemicarbazide or heterocyclic amines derivatives afford the novel sulfonamide derivatives. Furthermore, the reactivity of acetylsulfonamide derivatives towards nitrogen nucleophiles and dimedone afforded novel benzene sulfonamide compounds. Some of the synthesized chlorinated compounds exhibited excellent in vitro antitumor activity against HepG2 and MCF-7 cell lines. Additionally, further studies were carried out on one of the most effective compounds, 4-chloro-N-(4-(isoxazole-3-yl)phenyl) benzenesulfonamide 6a (ISP), to evaluate its potential interaction against KSHV thymidylate synthase complex. The comprehensive theoretical and experimental mechanical studies of compound 6a (ISP) were compatible with elemental analysis, FTIR, H-1 NMR and MS spectral data. The optimized molecular structure and the harmonic vibrational frequencies were examined via Density functional theory (DFT)/B3LYP/6-31G(d) and Hartree-Fock HF/6-31G(d) energies. (C) 2018 Elsevier B.V. All rights reserved.

Category: Triazoles. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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Du, XM; Wang, Z; Zhang, HY; Liu, WC; Chen, ZY; Xu, JM in [Du, Xinming; Wang, Zhe; Zhang, Hongyu; Liu, Wenchang; Chen, Zhaoyu; Xu, Jingmei] Changchun Univ Technol, Coll Chem Engn, Changchun 130012, Jilin, Peoples R China; [Du, Xinming; Wang, Zhe; Xu, Jingmei] Changchun Univ Technol, Adv Inst Mat Sci, Changchun 130012, Jilin, Peoples R China published Double network anion exchange membrane with excellent flexibility and stability in 2019.0, Cited 48.0. Application In Synthesis of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

A double-network anion exchange membrane (TA/AT-PEK/PVA-x) was prepared by Br-PEK and PVA, 3-amino-1,2,4 triazole forms a cross-linking structure with PVA under the action of 1,4-phthalaldehyde and then triazole can be linked with Br-PEK. The structure of membranes was verified by FT-IR. The composite membrane is uniform and smooth can be seen from the scanning electron microscope (SEM) and exhibit good hydrophilic/hydrophobic micro-phase separation structure proved by Transmission electron micrograph (TEM). The ionic conductivity of TA/AT-PEK/PVA-0.15 is 0.062 S/cm at 80 degrees C. With the addition of PVA within a certain range, the water uptake, swelling ratio hydroxide conductivity and alkaline stability are increase. The membranes are more flexible. After immersing in 4M NaOH solutions for 240 h at 80 degrees C, it remains at least 65% of its initial hydroxide ion conductivity of TA/AT-PEK/PVA-0.3 membrane. With the increasing number of water molecules solvating the hydroxide, its nucleophilicity and basicity were hindered, which enhance alkaline stability of anion exchange membranes.

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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An article Synthesis and application of amino triazolium-modified lactobionic acid as chiral selector in capillary electrophoresis WOS:000467665400021 published article about IONIC LIQUIDS; ENANTIOMERIC SEPARATION; BETA-CYCLODEXTRINS; ENANTIOSEPARATION; PERFORMANCE; COMPLEXES; MECHANISM; LIGAND; DRUGS; MODEL in [Liu, Jie; Du, Yingxiang; Sun, Xiaodong; Feng, Zijie; Ma, Xiaofei; Li, Jingtang] China Pharmaceut Univ, Dept Analyt Chem, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China; [Du, Yingxiang] China Pharmaceut Univ, Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Jiangsu, Peoples R China; [Du, Yingxiang] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China in 2019.0, Cited 39.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Computed Properties of C2H4N4

In this paper, a chiral selector, N-(4-H-1, 2, 4-triazolium)-lactobionamides (LA-ATM), was synthesized and applied for enantioseparation in capillary electrophoresis (CE) for the first time. Compared with lactobionic acid (LA) separation system, enhanced enantioseparation of five tested drugs was achieved in this modification system. In order to achieve good chiral separation, several parameters such as chiral selector concentration, buffer pH, applied voltage as well as the type and proportion of organic modifier were systematically investigated. Molecular modeling was applied to demonstrate the chiral recognition mechanism of the LA-ATM, which well supported the experimental results. Furthermore, a mathematical equation built up based on the molecular mechanics calculations was used in predicting resolution of tested drugs using LA or LA-ATM mediated CE, the predicted result was well correlated with the experimental result. (C) 2019 Published by Elsevier B.V.

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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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Recommanded Product: 61-82-5. Authors Fandzloch, M; Jedrzejewski, T; Dobrzanska, L; Esteban-Parra, GM; Wisniewska, J; Paneth, A; Paneth, P; Sitkowski, J in ROYAL SOC CHEMISTRY published article about in [Fandzloch, Marzena] Polish Acad Sci, Inst Low Temp & Struct Res, Okolna 2, PL-50422 Wroclaw, Poland; [Jedrzejewski, Tomasz] Nicolaus Copernicus Univ Torun, Fac Biol & Vet Sci, Dept Immunol, Lwowska 1, PL-87100 Torun, Poland; [Dobrzanska, Liliana; Wisniewska, Joanna] Nicolaus Copernicus Univ Torun, Fac Chem, Gagarina 7, PL-87100 Torun, Poland; [Esteban-Parra, Gines M.] Univ Granada, Dept Inorgan Chem, Avda Severo Ochoa S-N, Granada 18071, Spain; [Paneth, Agata] Med Univ Lublin, Fac Pharm, Dept Organ Chem, Chodzki 4a, PL-20093 Lublin, Poland; [Paneth, Piotr] Lodz Univ Technol, Fac Chem, Inst Appl Radiat Chem, Zeromskiego 116, PL-90924 Lodz, Poland; [Sitkowski, Jerzy] Natl Inst Med, Chelmska 30-34, PL-00725 Warsaw, Poland; [Sitkowski, Jerzy] Polish Acad Sci, Inst Organ Chem, Kasprzaka 44-52, PL-01224 Warsaw, Poland in 2021.0, Cited 91.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Three half-sandwich organometallic ruthenium(II) complexes containing purine analogs such as triazolo-pyrimidines of general formula [(eta(6)-p-cym)Ru(L)Cl-2], where p-cym represents p-cymene and L is 5,6,7-trimethyl-1,2,4-triazolo[1,5-alpyrimidine (tmtp for 1), 5,7-diethyl-1,2,4-triazolo[1,5-a]pyrimidine (detp for 2) and 5-methyl-1,2,4-triazolo(1,5-a]pyrimidin-7(4H)-one (HmtpO for 3), have been synthesized and characterized by elemental analysis, infrared, multinuclear magnetic resonance spectroscopic techniques (H-1, C-13, N-15), and single-crystal X-ray diffraction (for 1 and 2). All these complexes have been thoroughly screened for their in vitro cytotoxicity against MCF-7 and HeLa cell lines as well as L929 murine fibroblast cells, indicating [(eta(6)-p-cym)Ru(HmtpO)Cl-2] (3) as the most active representative against the HeLa cell line and simultaneously being 64-fold less toxic to normal L929 murine fibroblast cells than cisplatin. At the same time, 3 has shown antimetastatic activity comparable to NAMI-A against HeLa cells both after 24 and 48 h of treatment in a wound healing assay. in order to better understand the mechanism of anti-cancer action and differences in the cytotoxic activity of 1-3, the studies were expanded to determining their lipophilicity, the kinetic stability at pH 6.5-8, the effect on reactive oxygen species (ROS) production in HeLa cells and interactions with significant biomolecules (DNA and albumin) by using molecular docking and circular dichroism (CD) experiments. Furthermore, antiparasitic studies against L braziliensis, L. infantum and T cruzi reveal that the newly synthesized complexes 1-3 are very promising candidates which can compete with commercial antiparasitic drugs. Complex 3 in particular, on top of exhibiting high antiparasitic effect (IC50 < 1 mu M against two strains), reaches a selectivity index >1000.

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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

When did you first realize you had a special interest and talent inC2H4N4

Welcome to talk about 61-82-5, If you have any questions, you can contact Zhou, SR; Dong, Z; Yang, R; Wang, XY; Ye, ZW or send Email.. Recommanded Product: 61-82-5

Recommanded Product: 61-82-5. Authors Zhou, SR; Dong, Z; Yang, R; Wang, XY; Ye, ZW in WILEY-V C H VERLAG GMBH published article about in [Zhou, Shengren; Dong, Zhen; Yang, Rui; Wang, Xieyang; Ye, Zhiwen] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Peoples R China in 2021.0, Cited 24.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Two energetic compounds, erythritol tetranitrocarbamate (ETNC) and pentaerythritol tetranitrocarbamate (PETNC), and their salts, were synthesized in three steps, characterized and compared. All synthesized compounds were characterized by IR, DSC and multinuclear NMR spectroscopy. Four compounds were further investigated by single crystal X-ray diffraction. All nonmetal salts show extremely low mechanical sensitivity (IS >= 30 J; FS >= 360 N). The heats of formation were calculated using Gaussian 09, and the detonation performances were calculated using EXPLO 5. Although these nonmetal salts are lower than the neutral compounds ETNC (D: 7960 m s(-1), P: 27.4 GPa) and PETNC (D: 7629 m s(-1), P: 24.3 GPa), they possess high detonation performances that are better than TNT. Erythritol-based and corresponding pentaerythritol-based energetic materials were compared in terms of their thermostability, detonation velocity and detonation pressure. They were also compared in their respective series. ETNC and PETNC and their salts have short preparation steps and are easy to isolate in high yields, and thus have promising potential applications as explosives.

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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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An article Transition-metal-free N-arylation: A general approach to aza-fused poly-heteroaromatics WOS:000486513400001 published article about ONE-POT SYNTHESIS; EFFICIENT METHOD; INTRAMOLECULAR CYCLIZATION; OXIDATIVE AMINATION; C(SP(3))-H BONDS; DERIVATIVES; COPPER; PALLADIUM; BENZODIAZEPINE; INDOLES in [Annareddygari, Srikanth; Kasireddy, Venkateshwer Reddy] Jawaharlal Nehru Technol Univ, Dept Chem, Coll Engn, Hyderabad 500085, India; [Annareddygari, Srikanth; Reddy, Jayachandra] Dr JCR BIOSCEIENCES PRIVATE Ltd, Dept Res & Dev, Plot 79-80,Cherlapalli Phase 3 Ind Pk, Hyderabad 500039, India; [Kasireddy, Venkateshwer Reddy] Jawaharlal Nehru Technol Univ, Dept Chem, CMR Engn Coll, Hyderabad 501401, India in 2019.0, Cited 55.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

A new and efficient method for the synthesis of various aza-fused poly-hetero aromatics has been described. This protocol includes an intermolecular condensation followed by metal-free base-promoted intramolecular C?N coupling reaction. The advantage of this one-pot transformation lies in the use of simple cyclic amidines-like compounds without prefunctionalization of the starting heterocycles.

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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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Welcome to talk about 61-82-5, If you have any questions, you can contact van Onselen, R; Downing, TG or send Email.. Name: 1H-1,2,4-Triazol-5-amine

Name: 1H-1,2,4-Triazol-5-amine. van Onselen, R; Downing, TG in [van Onselen, Rianita; Downing, Tim G.] Nelson Mandela Univ, Dept Biochem & Microbiol, POB 77000, ZA-6031 Port Elizabeth, South Africa published beta-N-methylamino-L-alanine Inhibits Human Catalase Activity: Possible Implications for Neurodegenerative Disease Development in 2019.0, Cited 62.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

The naturally produced, nonprotein amino acid beta-N-methylamino-l-alanine (BMAA) has been proposed as a significant contributor to sporadic neurodegenerative disease development worldwide. However, the existing hypothesized mechanisms of toxicity do not adequately explain the role of BMAA in neurodegenerative disease development. There is evidence for BMAA-induced enzyme inhibition, but the effect of BMAA on human stress response enzymes has received little attention, despite the well-described role of oxidative stress in neurodegenerative disease development. The aim of this study was therefore to investigate the effect of BMAA on human catalase activity and compare it to the known inhibitor 3-amino-1,2,4-triazole. BMAA inhibited human erythrocyte catalase in a cell-free exposure to the same extent as the known inhibitor. Based on enzyme kinetics, the inhibition appears to be noncompetitive, possibly as a result of BMAA binding in the nicotinamide adenine dinucleotide phosphate (NADPH) binding site. BMAA-induced catalase inhibition was also observed in a human cell line culture. We therefore propose that BMAA-induced enzyme inhibition, specifically catalase inhibition, is a mechanism of toxicity that may contribute to the neurotoxicity of BMAA, further supporting the role of BMAA in neurodegenerative disease development.

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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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Quality Control of 1H-1,2,4-Triazol-5-amine. Suarez-Diez, M; Porras, S; Laguna-Teno, F; Schaap, PJ; Tamayo-Ramos, JA in [Suarez-Diez, Maria; Schaap, Peter J.] Wageningen Univ & Res, Lab Syst & Synthet Biol, Stippeneg 4, NL-6708 WE Wageningen, Netherlands; [Porras, Santiago] Univ Burgos, Dept Econ Aplicada, Plaza Infanta Dona Elena S-N, Burgos 09001, Spain; [Laguna-Teno, Felix; Tamayo-Ramos, Juan A.] Univ Burgos, Int Res Ctr Crit Raw Mat ICCRAM, Plaza Misael Banuelos S-N, Burgos 09001, Spain published Toxicological response of the model fungus Saccharomyces cerevisiae to different concentrations of commercial graphene nanoplatelets in 2020.0, Cited 92.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Graphene nanomaterials have attracted a great interest during the last years for different applications, but their possible impact on different biological systems remains unclear. Here, an assessment to understand the toxicity of commercial polycarboxylate functionalized graphene nanoplatelets (GN) on the unicellular fungal model Saccharomyces cerevisiae was performed. While cell proliferation was not negatively affected even in the presence of 800 mg L-1 of the nanomaterial for 24 hours, oxidative stress was induced at a lower concentration (160 mg L-1), after short exposure periods (2 and 4 hours). No DNA damage was observed under a comet assay analysis under the studied conditions. In addition, to pinpoint the molecular mechanisms behind the early oxidative damage induced by GN and to identify possible toxicity pathways, the transcriptome of S. cerevisiae exposed to 160 and 800 mg L-1 of GN was studied. Both GN concentrations induced expression changes in a common group of genes (337), many of them related to the fungal response to reduce the nanoparticles toxicity and to maintain cell homeostasis. Also, a high number of genes were only differentially expressed in the GN800 condition (3254), indicating that high GN concentrations can induce severe changes in the physiological state of the yeast.

Quality Control of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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Product Details of 61-82-5. In 2021.0 ENVIRON MOL MUTAGEN published article about NONGENOTOXIC CHEMICALS; RECOMMENDED LISTS; OXIDATIVE STRESS; FOLLOW-UP; ASSAY; PERFORMANCE; MUTAGENESIS; QUERCETIN; THRESHOLD; TESTS in [Allemang, Ashley; De Abrew, K. Nadira; Shan, Yuqing K.; Pfuhler, Stefan] Procter & Gamble Co, Global Prod Stewardship, Cincinnati, OH USA; [Krailler, Jesse M.] Procter & Gamble Co, Data & Modeling Sci, Cincinnati, OH USA in 2021.0, Cited 35.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

A key step in the risk assessment process of a substance is the assessment of its genotoxic potential. Irrespective of the industry involved, current approaches rely on combinations of two or three in vitro tests and while highly sensitive, their specificity is thought to be limited. A refined in vitro genotoxicity testing strategy with improved predictive capacity would be beneficial and 3R friendly as it helps to avoid unnecessary in vivo follow-up testing. Here, we describe a proof of concept study evaluating a balanced set of compounds that have in vivo negative or positive outcomes, but variable in vitro data, to determine if we could differentiate between direct and indirect acting genotoxicants. Compounds were examined in TK6 cells using an approach in which the same sample was used to evaluate both early genomic markers (Affymetrix analysis 4 hr post treatment), and the genotoxic outcome (micronuclei [MN] after 24 hr). The resulting genomic data was then analyzed using the TGx-DDI biomarker, Connectivity mapping and whole genome clustering. Chemicals were also tested in the ToxTracker assay, which uses six different biomarker genes. None of the methods correctly differentiated all direct from indirect acting genotoxicants when used alone, however, the ToxTracker assay, TGx-DDI biomarker and whole genome approaches provided high predictive capacity when used in combination with the MN assay (1/18, 2/18, 1/18 missed calls). Ultimately, a fit for purpose combination will depend on the specific tools available to the end user, as well as considerations of the unique benefits of the individual assays.

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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics