Month: November 2021

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis and evaluation of anti-tumor activity of novel triazolo[1,5-alpha] pyrimidine on cancer cells by induction of cellular apoptosis and inhibition of epithelial-to-mesenchymal transition process published in 2020.0. HPLC of Formula: C2H4N4, Reprint Addresses Safari, F (corresponding author), Univ Guilan, Fac Sci, Dept Biol, Rasht, Iran.; Bayat, M (corresponding author), Imam Khomeini Int Univ, Fac Sci, Dept Chem, Qazvin, Iran.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Cancer is a leading cause of human death worldwide. One of the greatest challenges in cancer therapy is the discovery and design of novel products with potential anti-tumor activities. In this study, a new protocol involves three-component condensation of the 3-amino-1,2,4-triazole as a 1,3-binucleophile, versatile aldehydes and Nmethyl-1-(methylthio)-2-nitroethenamine as an enamine analogous in the presence of trichloroacetic acid as a Bronsted-Lowry acidic promoter leads to new functionalized N-alkyl-6-nitro-3,5-dihydro-[1,2,4]triazolo [1,5-a] pyrimidin-7-amine in moderate to good yields. The presence of five nitrogen heteroatoms in the product structure has gathered immense attention among chemists and biologists due to their biological values. Therefore, we evaluated the anti-tumor activity of our synthetic compounds on different cancer cells including human malignant melanoma cells (A375), prostate cancer cells (PC3 cells, LNCaP cells) and normal cells HDF (human dermal fibroblast). Notably, we found that compound 4b that contains a nitro group has the best antitumor activity on three different cancer cells. By using DAPI staining, we showed cancer cells death. Apoptosis induction was shown using quantitative real time PCR (qRT-PCR) by evaluating of Bax and Bcl2 mRNA levels. Finally, we demonstrated that 4b has epithelial-to-mesenchymal transition (EMT) inhibition effect on cancer cells (by induction of E-cadherin and reduction of vimentin mRNA expression levels as two potential EMT markers). So, 4b could be an anti-cancer promising drug. Although, in vivo experiments will be required to evaluate possible side effects.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Name: 1H-1,2,4-Triazol-5-amine. In 2021.0 INT J BIOL MACROMOL published article about IN-VITRO; DERIVATIVES; PREDICTION; CHITOSANS in [Mi, Yingqi; Zhang, Jingjing; Tan, Wenqiang; Miao, Qin; Cui, Jingmin; Li, Qing; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Mi, Yingqi; Zhang, Jingjing; Tan, Wenqiang; Miao, Qin; Cui, Jingmin; Li, Qing; Guo, Zhanyong] Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China; [Mi, Yingqi; Miao, Qin; Cui, Jingmin; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Han, Xiangru] Yantai Univ, Coll Environm & Mat Engn, Yantai 264005, Peoples R China in 2021.0, Cited 30.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

A series of novel inulin derivatives were designed and synthesized by the introduction of amino heterocyclic moieties onto carboxymethyl inulin with the aid of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hyd roxysucci ni mide. The target products were prepared via three – step chemical synthesis, and structures were identified by FTIR and H-1 NMR spectroscopy. Antioxidant activities of inulin derivatives including DPPH – radical scavenging assay, superoxide – radical scavenging assay, hydroxyl – radical scavenging assay, and reducing power were estimated. Meanwhile, their antifungal activities, including Colletotrichum lagenarium and Bottytis cinerea, were also explored by hyphal measurement. In particular, inulin derivatives bearing heterocyclic moieties exhibited a remarkable improvement over inulin on antioxidant and antifungal activities, and their bioactivities decreased roughly in the order of 2ATCMI > 4APCMI > 3APCMI > 2APCMI > 3ATCMI > CMI > inulin. Furthermore, the cytotoxicities of inulin derivatives against L929 cells were evaluated by CCK-8 in vitro, and all samples showed weak cytotoxicities. In a nutshell, the paper provides a practical approach to synthesize novel inulin derivatives with dramatically enhanced bioactivity and good biocompatibility. The product described in paper might serve as a new leading structure for further design of antioxidants or antifungal agents in biomedicine, cosmetics, and other fields. (C) 2021 Elsevier B.V. All rights reserved.

Welcome to talk about 61-82-5, If you have any questions, you can contact Mi, YQ; Zhang, JJ; Han, XR; Tan, WQ; Miao, Q; Cui, JM; Li, Q; Guo, ZY or send Email.. Name: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Enhanced performance of pyrrolic N-doped reduced graphene oxide-modified glassy carbon electrodes for dopamine sensing WOS:000500386400013 published article about ELECTROCHEMICAL SENSOR; ASCORBIC-ACID; NITROGEN; FABRICATION; REDUCTION; NANOPARTICLES; HYDRAZINE; COMPOSITE; OXYGEN; HYBRID in [Wiench, Piotr; Gryglewicz, Stanislaw; Gryglewicz, Grazyna] Wroclaw Univ Sci & Technol, Fac Chem, Dept Polymer & Carbonaceous Mat, Gdanska 7-9, PL-50344 Wroclaw, Poland; [Gonzalez, Zoraida; Menendez, Rosa] CSIC, Inst Nacl Carbon INCAR, Francisco Pintado Fe 26, Oviedo 33011, Spain in 2019.0, Cited 60.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Two different nitrogen-doped reduced graphene oxides (N-rGOs) were used to modify glassy carbon electrodes (GCE/N-rGOs) as electrochemical sensors for the detection of dopamine (DA). For comparison, GCE/rGO was also studied. The N-rGOs were synthesized via hydrothermal treatment of graphene oxide (GO) with the N-dopants amitrole and urea. The resultant graphene materials exhibited distinct types and distributions of nitrogenated functional groups, but they possessed a similar oxygen content, thus avoiding interference from oxygenated groups. Pyridinic nitrogen was introduced into the rGO structure when amitrole was used as the N-dopant, whereas pyrrolic nitrogen was preferentially formed in the reaction with urea. After optimization of several experimental parameters and sensor calibration, the GCE/pyrrolic-N-rGO electrode was found to exhibit superior electrochemical performance compared with the pyridinic-N-rGO one, demonstrating a limit of detection and sensitivity of 335 nM and 3.51 mu A mu M-1, respectively. This sensor also showed better selectivity in the presence of interfering agents in the forms of ascorbic and uric acids. A significant improvement of sensor parameters can be explained in terms of the contribution of electrons derived from the pyrrolic structure to the delocalized C sp(2)-conjugated graphene system.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 J HETEROCYCLIC CHEM published article about ONE-POT SYNTHESIS; ASSISTED SYNTHESIS; REARRANGEMENT; HETEROCYCLES in [Kassem, Asmaa F.; Abbas, Eman M. H.] Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Chem Nat & Microbial Prod Dept, 33 Bohouth St,POB 12622, Giza, Egypt; [Al-Qurashi, Nadia T.] Umm Al Qura Univ, Univ Coll Adam, Dept Basic Sci, Mecca, Almukkarramah, Saudi Arabia; [Farghaly, Thoraya A.] Cairo Univ, Fac Sci, Dept Chem, Giza 1263, Egypt; [Farghaly, Thoraya A.] Umm Al Qura Univ, Fac Appl Sci, Dept Chem, Mecca 21514, Almukkarramah, Saudi Arabia in 2020.0, Cited 28.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. HPLC of Formula: C2H4N4

With aiding of microwave radiation, new series of fused-thiazolopyrimidines and fused-triazolopyrimidines each with cycloheptane have been synthesized through the reaction of cycloheptane-thione with alpha-haloketones or hydrazonoyl chlorides in short-time intervals as well as high yield. Moreover, reaction of 2,7-bis(2-chlorobenzylidene)cycloheptan-1-one with o-aminothiophenol and heterocyclic amines afforded benzo[b]cyclohepta[e][1,4]thiazepine derivative and cycloheptapyrimidines fused with different azoles, respectively. The structure for all products was discussed and proved based on the results of spectral data and elemental analysis. Evaluation of the antimicrobial activity of selected products indicated that most of derivatives showed their potent activity exceeds the reference antibiotic in some cases.

HPLC of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Kassem, AF; Abbas, EMH; Al-Qurashi, NT; Farghaly, TA or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Colorimetric aminotriazole assay based on catalase deactivation-dependent longitudinal etching of gold nanorods WOS:000477034000008 published article about CAPILLARY-ELECTROPHORESIS; PRECOLUMN DERIVATIZATION; LIQUID-CHROMATOGRAPHY; HERBICIDE AMITROLE; WATER SAMPLES; NANOPARTICLES; PESTICIDES; URAZOLE in [Li, Younan; Luo, Guoyan; Qing, Zhihe; Li, Xiaoxuan; Zou, Zhen; Yang, Ronghua] Changsha Univ Sci & Technol, Sch Chem & Food Engn, Hunan Prov Engn Res Ctr Food Proc Aquat Biot Reso, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Hunan, Peoples R China in 2019.0, Cited 35.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

A colorimetric and visual assay is described for the herbicide aminotriazole (ATZ). It is based on the etching of gold nanorods (AuNRs) by iodine which is formed on oxidation of iodide via H2O2. Longitudinal etching of the AuNRs occurs quickly and is accompanied by a color change from dark blue to red. In the absence of ATZ and the presence of active catalase (CAT), H2O2 is quickly decomposed into water, and the AuNRs will not be etched. In thepresence of ATZ, CAT is partially deactivated, and this affects the amount of available H2O2 and, consequently, of the iodine. Hence, the color is significantly changed. The color changes can be easily detected with bare eyes. The assay has a linear response in the 5 to 70 mu M concentration range, with a detection limit of 1.3 mu M and high selectivity for ATZ. It was applied to the determination of ATZ in water and food samples.

Safety of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Li, YN; Luo, GY; Qing, ZH; Li, XX; Zou, Z; Yang, R or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Product Details of 61-82-5. Iqbal, U; Choudhary, MI; Yousuf, S in [Iqbal, Urooj; Choudhary, M. Iqbal; Yousuf, Sammer] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Sindh, Pakistan published Synthesis of co-crystals of anti-cancer nandrolone as a potential leads towards treatment of cancer in 2021.0, Cited 30.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Co-crystals are emerging as members of supramolecular family having particular practical and fundamental significance for chemists, crystallographers, pharmaceutical scientists, and theoreticians. The presented study is focused to synthesize anti-cancer co-crystals of commercially available nandrolone (1), a synthetic anabolic-androgenic steroidal drug. Co-crystallization is done using economical and green grinding and reflux methods to obtain nandrolone (Nan): salicylic acid (Sal) and nandrolone (Nan): 3-amino-1,2,4-triazole (Triz) co-crystals, in 2:1 and 1:1 stoichiometric ratios, respectively. The structural analysis and characterization were carried out using single-crystal X-ray diffraction, and vibrational spectroscopy. Nandrolone (1) crystallizes in monoclinic P2(1) space group, while the co-crystal-I (Nan:Sal) and co-crystal-II (Nan:Triz), co-crystallized in the orthorhombic P2(1)2(1)2(1) space group. The intermolecular hydrogen bonds O-H center dot center dot center dot O, C-H center dot center dot center dot O, N-H center dot center dot center dot O, O-H center dot center dot center dot N, and N-H center dot center dot center dot N between the active pharmaceutical ingredient (nandrolone) and co-formers (salicylic acid, and 3-amino-1,2,4-triazole) stabilize the structures of cocrystals. In vibrational spectroscopy of co-crystal-I (Nan:Sal), the blue shifts in stretching frequencies of hydroxyl group from 3417.9 cm(-1) to 3427.8 cm(-1) further supported the hydrogen bond interactions between API and co-former. Similarly, in co-crystal-II (Nan:Triz) the NH2 stretching frequency from 3331.4- 3413.4 cm(-1) to 3312.7 cm(-1), supported the interaction of NH2 with API via intermolecular interaction. Nandrolone (1) and both co-crystals were found to be non-cytotoxic against 3T3 normal fibroblast cell line. Nandrolone (IC50 = 1.0 0.1 mu M), co-crystal-I (Nan:Sal) (IC50 = 1.6 +/- 0.3 mu M) and-II (Nan:Triz) (IC50 = 1.8 +/- 0.1 mu M) showed anti-cancer potential against cervical cancer HeLa cell line. While doxorubicin (IC50 = 1.2 +/- 0.2 mu M) was used as standard tested compound. SYNOPSIS Two new non-cytotoxic co-crystals of synthetic anabolic-androgenic steroidal drug nandrolone (Nan) with pharmaceutically acceptable salicylic acid (Sal), and triazole (Triz) were synthesized and their structures were elucidated using single-crystal X-ray diffraction, and vibrational spectroscopy. Quantitative analysis of -OH and -NH2 intermolecular interactions between API and co-former by Hirshfeld surface analysis further supported the role of various functionalities towards the stability of co-crystals. Both co-crystals were found to be non-cytotoxic against 3T3 normal fibroblast cell line. Co-crystal-I (Nan:Sal) and co-crystal-II (Nan:Triz) were found to be selectively active against HeLa cancer cell line (IC50 = 1.6 +/- 0.3 mu M), (IC50 = 1.8 +/- 0.1 mu M). (c) 2020 Elsevier B.V. All rights reserved.

Product Details of 61-82-5. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Development of a Multiresidue Method for Endocrine-Disrupting Pesticides by Solid Phase Extraction and Determination by UHPLC-MS/MS from Drinking Water Samples WOS:000537475500002 published article about TANDEM MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN HEALTH-RISK; ORGANOCHLORINE PESTICIDES; TRACE DETERMINATION; POLAR PESTICIDES; HPLC-DAD; PHARMACEUTICALS; RIVER; SPE in [Liu, Shaoying; Huang, Xihui; Hu, Kejun; Jin, Quan] Hangzhou Ctr Dis Control & Prevent, Lab Chem & Phys, Hangzhou, Peoples R China; [Zhu, Guonian] Zhejiang Univ, Inst Pesticide & Environm Toxicol, Hangzhou, Peoples R China in 2020.0, Cited 44.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Recommanded Product: 1H-1,2,4-Triazol-5-amine

A rapid and efficient method based on solid phase extraction and liquid chromatography-tandem mass spectrometry was validated, allowing the determination of the endocrine-disrupting herbicides (acetochlor, alachlor, amitrole and atrazine), fungicides (carbendazim, triadimefon, penconazole and propiconazole), and insecticides (carbaryl and carbofuran) in drinking water. Low method detection limits (0.01-0.64 ng/L) and method quantification limits (0.03-2.13 ng/L) were obtained with satisfactory recoveries and precision for the endocrine-disrupting pesticides. The method was applied for real drinking water samples collected in the area of the city of Hangzhou (Zhejiang, China); the results showed that carbendazim, atrazine and acetochlor were detected in the drinking water samples and acetochlor was the most detected analyte.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. I found the field of Chemistry very interesting. Saw the article DBU Catalysis: An Efficient Synthetic Strategy for 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidines published in 2020.0, Reprint Addresses Singh, RK (corresponding author), Univ Allahabad, Dept Chem, Bioorgan Res Lab, Allahabad 211002, Uttar Pradesh, India.; Singh, J (corresponding author), Univ Allahabad, Dept Chem, Environm Benign Synth Lab, Allahabad 211002, Uttar Pradesh, India.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

Aims and Objectives: An efficient and facile DBU catalysed synthesis of highly significant motif 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidines under solvent-free condition has been reported. Materials and Methods: To a round bottom flask, 1.0 mmol of chalcone (1), 1.5 mmol of 3-amino-1,2,4-triazole (2) and 30 mol% of DBU were added at 70 degrees C and stirred in solvent-free condition. After the completion of the reaction (monitored by TLC), water (10 ml) was added. The aqueous layer was extracted with ethyl acetate (3 x 10 ml). The combined organic layers were dried over anhydrous Na2SO4. The combined organic layers were evaporated under reduced pressure and the resulting crude product was purified by column chromatography by using ethyl acetate and hexane as eluent. Results: Reaction using chalcone and 3-amino-1,2,4-triazole as model substrates were carried out under different reaction conditions and it was observed that 30 mol% of DBU under the solvent-free condition at 70 degrees C was the optimum temperature for the proposed synthesis. Conclusion: Use of DBU (an organocatalyst) as a base, operational simplicity, high yield of products and short reaction time are some of the significant advantages associated with the proposed strategy.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Liu, J; Wei, YH; Bao, FL; Li, GX; Liu, HY; Wang, HY in [Liu, Jie; Wei, Yuhui; Bao, Fenlin; Li, Guixiang; Liu, Huiyan; Wang, Haiying] Jiangsu Normal Univ, Jiangsu Key Lab Green Synthet Chem Funct Mat, Sch Chem & Mat Sci, Xuzhou 221116, Jiangsu, Peoples R China published Pore-size tuning in pillared-layer metal-organic framework with self-penetrated rob net for selective gas adsorption and efficient dyes adsorption in aqueous solution in 2019.0, Cited 45.0. Quality Control of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Two metal-organic frameworks, [Zn-2(atrz)(2)(bpdc)]center dot 0.5H(2)O (1) and [Zn-2(mtrz)(2)(azdc)]center dot DMA center dot CH3OH center dot H2O (2), with 3-substitued 1,2,4-triazole (Hatrz = 3-amino-1,2,4-triazole, Hmtrz = 3-methyl-1,2,4-triazole) have been constructed. Both MOFs possess 3D self-penetrated frameworks featuring Zn-triazolate layers pillared by dicarboxylate ligands (H(2)bdc = 1,4-benzenedicarboxylate, H(2)azdc = azobenzene-4,4′-dicarboxylate). In particular, 2 exhibits a rare rob network with the dimeric Zn-triazolate as the 6-connected nodes, which resulted from the synergistic effects of both 3-substitued group of triazolate and size-alterable dicarboxylate pillar on the final frameworks. Detailed structural analysis of 1 and 2 and its comparison with commonly observed pcu net in pillared-layer structure has been presented. Pore-size tuning and functionalities have also been achieved related to diverse molecular length of pillars. 2 with long pillar displays suitable pore size, and consequently, demonstrates selective CO2 uptake and efficient dyes adsorption in aqueous solution based on size-exclusion effect. (C) 2019 Elsevier Ltd. All rights reserved.

Quality Control of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Liu, J; Wei, YH; Bao, FL; Li, GX; Liu, HY; Wang, HY or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about ETIOTROPIC THERAPY; INFLUENZA; PRECURSOR; ARVI, Saw an article supported by the Russian Science FoundationRussian Science Foundation (RSF) [20-13-00142]. Published in SPRINGER in NEW YORK ,Authors: Drokin, RA; Tiufiakov, DV; Voinkov, EK; Slepukhin, PA; Ulomsky, EN; Esaulkova, YL; Volobueva, AS; Lantseva, KS; Misyurina, MA; Zarubaev, VV; Rusinov, VL. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

An azo coupling reaction of alpha-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1-c][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics