Day: October 25, 2021

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Recently I am researching about P53 TUMOR-SUPPRESSOR; CRYSTAL-STRUCTURE; COMPLEXES; SYSTEM, Saw an article supported by the Qatar Foundation Biomedical Research Program (BMRP) grant; Weill Cornell Medicine in Qatar pilot grant. Published in AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC in ROCKVILLE ,Authors: Andrews, SS; Schaefer-Ramadan, S; Al-Thani, NM; Ahmed, I; Mohamoud, YA; Malek, JA. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Two-hybrid systems can be used for investigating protein-protein interactions and may provide important information about gene products with unknown function. Despite their success in mapping protein interactions, two-hybrid systems have remained mostly untouched by improvements in next-generation DNA sequencing. The two-hybrid systems rely on one-versus-all methods in which each bait is sequentially screened against an entire library. Here, we developed a screening method that joins both bait and prey as a convergent fusion into one bacterial plasmid vector that can then be amplified and paired-end sequencing by next-generation sequencing (NGS). Our method enables all-versus-all sequencing (AVA-Seq) and utilizes NGS to remove multiple bottlenecks of the two-hybrid system. AVA-Seq allows for high-resolution protein-protein interaction mapping of a small set of proteins and has the potential for lower-resolution mapping of entire proteomes. Features of the system include ORF selection to improve efficiency, high bacterial transformation efficiency, a convergent fusion vector to allow paired-end sequencing of interactors, and the use of protein fragments rather than full-length proteins to better resolve specific protein contact points. We demonstrate the system’s strengths and limitations on a set of proteins known to interact in humans and provide a framework for future large-scale projects.

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Andrews, SS; Schaefer-Ramadan, S; Al-Thani, NM; Ahmed, I; Mohamoud, YA; Malek, JA or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Aqueous-Phase Temperature Swing Adsorption for Pesticide Removal WOS:000456349900039 published article about CARBON-DIOXIDE CAPTURE; ACTIVATED CARBON; WATER-PURIFICATION; DYNAMIC PRINCIPLE; LIQUID WATER; CO2 CAPTURE; REGENERATION; KINETICS; SURFACE; EQUILIBRIUM in [Aumeier, Benedikt M.; Dang, Anh H. Q.; Ohs, Burkhard; Yuece, Sueleyman; Wessling, Matthias] Rhein Westfal TH Aachen, Aachener Verfahrenstech, Chem Proc Engn, Forckenbeckstr 51, D-52074 Aachen, Germany; [Wessling, Matthias] DWI Leibniz Inst Interact Mat, Forckenbeckstr 50, D-52074 Aachen, Germany in 2019.0, Cited 67.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. SDS of cas: 61-82-5

Recently, activated carbon adsorption for water treatment regained substantial attention due to the emerging task to remove trace organic compounds such as pesticides. In many applications, especially in decentralized water treatment, one major drawback of adsorbents is their limited recyclability due to inadequate logistics or uneconomical reactivation. In this lab-scale study, we present the temperature swing adsorption in the aqueous phase that allows the in situ regeneration of fixed-bed adsorbers, and prove its technical feasibility. Complying with circular water economy principles, we eliminated the pivotal need for regular replacement and consumables by employing only clean water instead of dedicated regeneration solutions. Adsorption of the herbicide amitrole in aqueous solution on granular activated carbon was exothermic (Delta H = -14.4 +/- 3.2 kJ mol(-1) for T = 20-94 degrees C) and followed the Freundlich model. The proposed method consisting of a short counterflow flush with liquid water at 125 degrees C effectively regenerated the adsorbent. Hence, we obtained a cyclic steady state operation with breakthrough after 122 +/- 14 bed volumes (at c(out)/c(in) = 0.2), cycle-average rejection of 90 +/- 1%, and water recovery of up to 78 +/- 4%. No thermal aging of adsorbent was observed over the investigated 17 cycles.

SDS of cas: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Aumeier, BM; Dang, AHQ; Ohs, B; Yuce, S; Wessling, M or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019.0 POLYM CHEM-UK published article about POLY N-ISOPROPYLACRYLAMIDE; IONIC LIQUID; TUNABLE LCST; POLY(IONIC LIQUID); BEHAVIOR; POLY(N-ISOPROPYLACRYLAMIDE); THERMO; PH; HOMOPOLYMERS; CO2 in [Li, Jin-Jin; Zhou, Yin-Ning; Zhu, Shiping] McMaster Univ, Dept Chem Engn, Hamilton, ON L8S 4L7, Canada; [Li, Jin-Jin; Zhou, Yin-Ning; Luo, Zheng-Hong] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Dept Chem Engn, Shanghai 200240, Peoples R China; [Zhu, Shiping] Chinese Univ Hong Kong, Sch Sci & Engn, Shenzhen 518172, Peoples R China in 2019.0, Cited 50.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

A thermo-responsive copolymer with a gas-switchable LCST-type phase transition was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization of N-isopropylacrylamide (NIPAM) and glycidyl methacrylate (GMA), followed by post-polymerization functionalization with sodium 3-amino-1,2,4-triazole (ATANa). Incorporating ionic moieties provides an elevated cloud point of 61 degrees C. Importantly, both CO2 and SO2 cause a reduction in the cloud point of the polymer solution. The CO2-triggered system can be easily and fully recovered to its initial state by introducing an inert gas (e.g. N-2), whereas the SO2-triggered system shows only partial recovery. The pH-dependent phase transition behaviors confirm that the gas bubbling-induced pH changes contribute to the gas-switchable cloud point of P(NIPAM-co-(GMA-ATANa)). In addition, P(NIPAM-co-(GMA-ATA)) (ATA: 3-amino-1,2,4-triazole), a counterpart of P(NIPAM-co-(GMA-ATANa)), was prepared and the relevant solution phase transition behavior was studied. Its cloud point shift in response to gas bubbling and pH adjustment is opposite to that of P(NIPAM-co-(GMA-ATANa)), indicating that the latter does not result from the protonation of amidine groups. Alternatively, a reversible H+-induced decrease in hydrophilicity was thus proposed. This contribution enriches the family of thermo-responsive polymers by introducing gas-sensitive polyelectrolytes and also broadens the scope of gas-responsive smart materials.

Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Li, JJ; Zhou, YN; Luo, ZH; Zhu, SP or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 61-82-5. In 2019.0 J HETEROCYCLIC CHEM published article about ANTIOXIDANT ACTIVITIES; ESSENTIAL OIL in [Mabkhot, Yahia Nasser] King Khalid Univ, Coll Pharm, Dept Pharmaceut Chem, Abha, Saudi Arabia; [Kaal, Nahed Ahmed; Alterary, Seham] King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia; [Mubarak, Mohammad S.] Univ Jordan, Dept Chem, Amman 11942, Jordan; [Alsayari, Abdulrhman; Bin Muhsinah, Abdullatif] King Khalid Univ, Coll Pharm, Dept Pharmacognosy, Abha, Saudi Arabia in 2019.0, Cited 25.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Phenacylbromide derivatives constitute a multilateral group of precursors for the synthesis of numerous heterocycles of organic compounds. Briefly, 5-(2-bromo-acetyl)-substituted-thiophene derivative has been used as a synthon for synthesis of new thiophene-containing compounds through the reaction with nucleophilic nitrogen compounds and thioamides. The suggested structures of the newly synthesized thiophene compounds were confirmed and assured with different spectroscopic tools and with CHN elemental analysis. Additionally, the antimicrobial activity of these thiophene compounds was recorded to investigate their potency against various types of bacteria and fungi. Results showed that these compounds exhibit significant inhibitory activity against the growth of tested bacterial and fungal strains and that some derivatives were more potent than the employed reference drugs.

Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mabkhot, YN; Kaal, NA; Alterary, S; Mubarak, MS; Alsayari, A; Bin Muhsinah, A or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Science & Technology – Other Topics very interesting. Saw the article Toxicological response of the model fungus Saccharomyces cerevisiae to different concentrations of commercial graphene nanoplatelets published in 2020.0. Formula: C2H4N4, Reprint Addresses Tamayo-Ramos, JA (corresponding author), Univ Burgos, Int Res Ctr Crit Raw Mat ICCRAM, Plaza Misael Banuelos S-N, Burgos 09001, Spain.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Graphene nanomaterials have attracted a great interest during the last years for different applications, but their possible impact on different biological systems remains unclear. Here, an assessment to understand the toxicity of commercial polycarboxylate functionalized graphene nanoplatelets (GN) on the unicellular fungal model Saccharomyces cerevisiae was performed. While cell proliferation was not negatively affected even in the presence of 800 mg L-1 of the nanomaterial for 24 hours, oxidative stress was induced at a lower concentration (160 mg L-1), after short exposure periods (2 and 4 hours). No DNA damage was observed under a comet assay analysis under the studied conditions. In addition, to pinpoint the molecular mechanisms behind the early oxidative damage induced by GN and to identify possible toxicity pathways, the transcriptome of S. cerevisiae exposed to 160 and 800 mg L-1 of GN was studied. Both GN concentrations induced expression changes in a common group of genes (337), many of them related to the fungal response to reduce the nanoparticles toxicity and to maintain cell homeostasis. Also, a high number of genes were only differentially expressed in the GN800 condition (3254), indicating that high GN concentrations can induce severe changes in the physiological state of the yeast.

Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Suarez-Diez, M; Porras, S; Laguna-Teno, F; Schaap, PJ; Tamayo-Ramos, JA or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article The Role of Micropores and Amino Groups in Preferential CO2 Adsorptivity of Porous Zn-Coordination Polymers Comprising Mixed Ligands of Triazole and Amino Triazole published in 2019.0. Recommanded Product: 61-82-5, Reprint Addresses Zubir, M (corresponding author), State Univ Medan, Fac Math & Nat Sci, Chem Dept, Jl Willem Iskandar,Pasar 5,Medan Estate, Medan 20221, North Sumatera, Indonesia.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Porous coordination polymers (PCPs) of Zn2+, oxalic acid and mixture ratio of 3-amino, 1,2,4-triazole (Ataz) and 1,2,4-triazole (Taz) were synthesized to capture of carbon dioxide. A series of molar fraction Taz/(Taz + ATaz) prepared as 0.1;0.3;0.4;0.5;0.6;0.7 and 0.9 and also only ATaz and Taz ligand as 0 and 1 molar fraction respectively. Mixture of Taz and ATaz crystal induce new structure of 0.4, 0.5 and 0.6 molar fraction. Nitrogen adsorption of 50% mixture each ligand contribute the highest surface area as function of optimum condition to integrate pore space and amine group presence with adsorbed as 290 mgg(-1). This phenomena also shown through CO2 adsorption amount as 135 mgg(-1), instead of 0.4, 0.6 and 0.7 molar fraction observed higher amount of CO2 compared with only Taz ligand (X=1), indicate the integrated effects both of the ligand could generated the capture of higher amount of carbon dioxide.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zubir, M; Nasutioni, HI; Sudarma, TF or concate me.. Recommanded Product: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Name: 1H-1,2,4-Triazol-5-amine. I found the field of Plant Sciences very interesting. Saw the article The root-knot nematode effector MiPDI1 targets a stress-associated protein (SAP) to establish disease in Solanaceae andArabidopsis published in 2020.0, Reprint Addresses Jian, H (corresponding author), China Agr Univ, Minist Agr, Dept Plant Pathol, Beijing 100193, Peoples R China.; Jian, H (corresponding author), China Agr Univ, Minist Agr, Key Lab Pest Monitoring & Green Management, Beijing 100193, Peoples R China.; Favery, B (corresponding author), Univ Cote dAzur, INRAE, CNRS, ISA, F-06903 Sophia Antipolis, France.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

Large amounts of effectors are secreted by the oesophageal glands of plant-parasitic nematodes, but their molecular mode of action remains largely unknown. We characterized aMeloidogyne incognitaprotein disulphide isomerase (PDI)-like effector protein (MiPDI1) that facilitates nematode parasitism. In situhybridization showed thatMiPDI1was expressed specifically in the subventral glands ofM. incognita. It was significantly upregulated during parasitic stages. Immunolocalization demonstrated MiPDI1 secretionin plantaduring nematode migration and within the feeding cells. Host-induced silencing of theMiPDI1gene affected the ability of the nematode to infect the host, whereasMiPDI1expression inArabidopsisincreased susceptibility toM. incognita, providing evidence for a key role of MiPDI1 inM. incognitaparasitism. Yeast two-hybrid, bimolecular fluorescence complementation and coimmunoprecipitation assays showed that MiPDI1 interacted with a tomato stress-associated protein (SlSAP12) orthologous to the redox-regulated AtSAP12, which plays an important role in plant responses to abiotic and biotic stresses.SAP12silencing or knocking out inNicotiana benthamianaand Arabidopsis increased susceptibility toM. incognita. Our results suggest that MiPDI1 acts as a pathogenicity factor promoting disease by fine-tuning SAP-mediated responses at the interface of redox signalling, defence and stress acclimation in Solanaceae andArabidopsis.

Name: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zhao, JL; Mejias, J; Quentin, M; Chen, YP; de Almeida-Engler, J; Mao, ZC; Sun, QH; Liu, Q; Xie, BY; Abad, P; Favery, B; Jian, H or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Biochemistry & Molecular Biology very interesting. Saw the article Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins published in 2019.0. Product Details of 61-82-5, Reprint Addresses Kapoor, TM (corresponding author), Rockefeller Univ, Lab Chem & Cell Biol, New York, NY 10065 USA.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Drug-like inhibitors are often designed by mimicking cofactor or substrate interactions with enzymes. However, as active sites are comprised of conserved residues, it is difficult to identify the critical interactions needed to design selective inhibitors. We are developing an approach, named RADD (resistance analysis during design), which involves engineering point mutations in the target to generate active alleles and testing compounds against them. Mutations that alter compound potency identify residues that make key interactions with the inhibitor and predict target-binding poses. Here, we apply this approach to analyze how diaminotriazole-based inhibitors bind spastin, a microtubule-severing AAA (ATPase associated with diverse cellular activities) protein. The distinct binding poses predicted for two similar inhibitors were confirmed by a series of X-ray structures. Importantly, our approach not only reveals how selective inhibition of the target can be achieved but also identifies resistance-conferring mutations at the early stages of the design process.

Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Pisa, R; Cupido, T; Steinman, JB; Jones, NH; Kapoor, TM or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Development of a Multiresidue Method for Endocrine-Disrupting Pesticides by Solid Phase Extraction and Determination by UHPLC-MS/MS from Drinking Water Samples WOS:000537475500002 published article about TANDEM MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN HEALTH-RISK; ORGANOCHLORINE PESTICIDES; TRACE DETERMINATION; POLAR PESTICIDES; HPLC-DAD; PHARMACEUTICALS; RIVER; SPE in [Liu, Shaoying; Huang, Xihui; Hu, Kejun; Jin, Quan] Hangzhou Ctr Dis Control & Prevent, Lab Chem & Phys, Hangzhou, Peoples R China; [Zhu, Guonian] Zhejiang Univ, Inst Pesticide & Environm Toxicol, Hangzhou, Peoples R China in 2020.0, Cited 44.0. Name: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

A rapid and efficient method based on solid phase extraction and liquid chromatography-tandem mass spectrometry was validated, allowing the determination of the endocrine-disrupting herbicides (acetochlor, alachlor, amitrole and atrazine), fungicides (carbendazim, triadimefon, penconazole and propiconazole), and insecticides (carbaryl and carbofuran) in drinking water. Low method detection limits (0.01-0.64 ng/L) and method quantification limits (0.03-2.13 ng/L) were obtained with satisfactory recoveries and precision for the endocrine-disrupting pesticides. The method was applied for real drinking water samples collected in the area of the city of Hangzhou (Zhejiang, China); the results showed that carbendazim, atrazine and acetochlor were detected in the drinking water samples and acetochlor was the most detected analyte.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Liu, SY; Huang, XH; Hu, KJ; Jin, Q; Zhu, GN or concate me.. Name: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Electrocatalytic behavior of a heterostructured nanocomposite sensor for aminotriazole published in 2020.0. Formula: C2H4N4, Reprint Addresses Malode, SJ; Shetti, NP (corresponding author), KLE Inst Technol, Ctr Electrochem Sci & Mat, Dept Engn Chem, Hubballi 580027, Karnataka, India.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Aminotriazole (AT), an organic heterocyclic compound, is an unselective herbicide used to deal with a large assortment of weeds by preventing the biosynthesis of carotenoids. It is a malignant agent to human beings as well as to animals. This study is focused on the nanomolar detection of AT with multiwalled carbon nanotubes along with calcium-doped zinc oxide nanoparticles adapted for a nano-composite dependent glassy carbon electrode (MWCNTs/Ca-ZnO/GCE). The developed MWCNTs/Ca-ZnO/GCE showed an excellent electrocatalytic response to AT in 3.0 pH of 0.2 M phosphate buffer solution (PBS). There was an increase in the peak current of AT, i.e., 7.726 mu A, with MWCNTs/Ca-ZnO/GCE when it was compared with the peak current of AT at the bare glassy carbon electrode (GCE), 3.478 mu A, due to the semiconducting properties of the doped nanoparticles. Various techniques were employed to study the different parameters such as scan rate, pH variations, and concentration variations by cyclic voltammetry (CV), square wave voltammetry (SWV), and linear sweep voltammetry (LSV) in order to probe the mechanism, number of participating electrons, type of process, detection limit, and quantification limit. The Ca-ZnO nanoparticles (NPs) were synthesized at the proportion of 5.0% and these were characterized by energy dispersive X-ray analysis (EDX), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). The developed sensor was applied for real sample analysis like soil and water by quantifying the AT in the samples and the output was found to be precise with good recovery results.

Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Malode, SJ; Prabhu, KK; Shetti, NP or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics