Analyzing the synthesis route of 16681-70-2

The synthetic route of 16681-70-2 has been constantly updated, and we look forward to future research findings.

16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, belongs to triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C3H3N3O2

Preparation 1 1-Trityl-1H-1,2,3-triazole-4-carboxylic Acid 1H-1,2,3-Triazole-4-carboxylic acid (20.0 g, 177 mmol) was combined with DMF (200 mL, 2.6 mol) and pyridine (100 mL, 1.2 mol), and the resulting mixture was cooled to 0 C. Triphenylmethyl chloride (54 g, 190 mmol) was added in portions and the mixture was stirred at room temperature for 24 hours. The resulting slurry was filtered and the filter cake was washed with water (2*200 mL) and air-dried yield an off white solid (60 g). The solid was slurried in THF (800 mL) at room temperature for 4 hours, then filtered. The filtrate was then concentrated by rotary evaporation, yielding a thick oil. EtOAc (500 mL) was added and the volume was reduced to 200 mL. The resulting thick slurry was filtered and dried to yield the title compound (35.5 g).

The synthetic route of 16681-70-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fleury, Melissa; Hughes, Adam D.; US2014/45906; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The origin of a common compound about 1001401-62-2

According to the analysis of related databases, 1001401-62-2, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1001401-62-2 as follows. Safety of 2-(2H-1,2,3-Triazol-2-yl)benzoic acid

To a solution of 12.0 g (42.3 mmol) of the hydrochloride salt of F-1, 8.8 g (46.6 mmol) A-1, 6.92 g (50.8 mmol) 1-hydroxy-7-azabenzotriazole, and 18.6 mL (169 mmol) N-methylmorpholine in 200 mL of DMF was added 12.2 g (63.5 mmol) EDC and the reaction was stirred overnight at room temperature. The reaction was partitioned between EtOAc and 10% aqueous KHSO4, washed with water, saturated aqueous NaHCO3, water, brine, dried over MgSO4, and concentrated by rotary evaporation. The previous acidic and basic layers were extracted again with EtOAc. The organic extract was washed with brine, dried, concentrated and combined with the organic residue from above. The total amount of residue was purified by column chromatography on silica gel (EtOAc/hexanes) to provide F-2 as a colorless oil. Data for F-2: LC/MS: rt=2.25 min; m/z (M+H)=420.3 found; 420.5 required.

According to the analysis of related databases, 1001401-62-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bergman, Jeffrey M.; Breslin, Michael J.; Coleman, Paul J.; Cox, Christopher D.; Mercer, Swati P.; Roecker, Anthony J.; US2008/132490; (2008); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Some tips on 3641-13-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, its application will become more common.

Synthetic Route of 3641-13-2,Some common heterocyclic compound, 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, molecular formula is C3H4N4O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Add 90 mL of anhydrous methanol to a 250 mL three-necked flask. Take 12.8 g (10 mmol) of 3-amino-1H-1,2,4-triazole-5carboxylic acid, Stir it in anhydrous methanol. Take 6mL of 50% fuming H2SO4 and slowly add it to the reaction solution. The temperature was raised to 85 C and refluxed for 12 h. Naturally cooled, rotary distillation to remove some methanol, Precipitation gave precipitation of methyl 3-amino-1H-1,2,4-triazole-5-carboxylate sulfate. Add 20 mL of distilled water to the precipitate, and adjust the pH to 5-6 with NaOH (5 mol¡¤L-1). Filtered to give a white precipitate. Wash 2-3 times with absolute ethanol, Drying gave methyl 3-amino-1H-1,2,4-triazole-5-carboxylate (yield: 73%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, its application will become more common.

Reference:
Patent; China Engineering Physics Institute Chemical Materials Institute; Zhang Qi; Wang Tingwei; Chen Dong; Li Hongzhen; (10 pag.)CN109096215; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Sources of common compounds: 135242-93-2

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (1-Methyl-1H-[1,2,4]triazol-3-yl)methanol, and friends who are interested can also refer to it.

Related Products of 135242-93-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 135242-93-2 name is (1-Methyl-1H-[1,2,4]triazol-3-yl)methanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of (l-methyl-l/-/-l,2,4-triazol-3-yl)methanol (400 mg, 3.54 mmol) and iodobenzene diacetate (1.25 g, 3.89 mmol) in dichloromethane (10 mL) was added TEMPO ((2, 2,6,6- tetramethylpiperidin-l-yl)oxyl) (56 mg, 354 pmol). The mixture was stirred at 15-20C for 2h. The mixture was concentrated in vacuo. The residue was purified by silica gel chromatography (petroleum ethenethyl acetate = 1:2) to give l-methyl-l/-/-l,2,4-triazole-3-carbaldehyde (300 mg, 2.70 mmol, 76% yield). XH NMR (chloroform-d 400 MHz) d 10.01 (s, 1H), 8.19 (s, 1H), 4.06 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (1-Methyl-1H-[1,2,4]triazol-3-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; JUHL, Karsten; MARIGO, Mauro; VITAL, Paulo, Jorge, Vieira; JESSING, Mikkel; LANGGARD, Morten; RASMUSSEN, Lars, Kyhn; CLEMENTSON, Carl, Martin, Sebastian; (278 pag.)WO2019/115567; (2019); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New learning discoveries about 40253-47-2

Statistics shows that Ethyl 5-methyl-1H-1,2,4-triazole-3-carboxylate is playing an increasingly important role. we look forward to future research findings about 40253-47-2.

Synthetic Route of 40253-47-2, These common heterocyclic compound, 40253-47-2, name is Ethyl 5-methyl-1H-1,2,4-triazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of ethyl 3 -methyl- 1H- 1 ,2,4-triazole-5-carboxylate in anhydrous DMF was treated with sodium hydride (60 wtpercent in mineral oil, 1.2 equiv.) and stirred for 10 min. 2- Fluorobenzyl bromide (1.2 equiv.) was added. After 16 hours, water was added and the aqueous phase was extracted with ethyl acetate. The combined organic phases were washed with water and brine, dried over sodium sulfate, filtered, and the solvent was removed in vacuo. Purification by silica gel chromatography (10-50percent ethyl acetate in hexanes gradient) yielded ethyl l-(2-fluorobenzyl)-5-methyl-lH-l,2,4-triazole-3-carboxylate (58percent) and ethyl 1 -(2-fluorobenzyl)-3-methyl- 1H- 1 ,2,4-triazole-5-carboxylate (23percent)

Statistics shows that Ethyl 5-methyl-1H-1,2,4-triazole-3-carboxylate is playing an increasingly important role. we look forward to future research findings about 40253-47-2.

Reference:
Patent; IRONWOOD PHARMACEUTICALS, INC.; RENNIE, Glen Robert; PERL, Nicholas; MERMERIAN, Ara; JUNG, Joon; JIA, James; IYENGAR, Rajesh R.; IM, G-Yoon Jamie; BARDEN, Timothy Claude; SHEPPECK, James Edward; RENHOWE, Paul Allan; NAKAI, Takashi; LEE, Thomas Wai-Ho; IYER, Karthik; (346 pag.)WO2016/44446; (2016); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The origin of a common compound about 162848-16-0

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 162848-16-0, name is 4-[1,2,4]Triazol-1-yl-benzoic acid, A new synthetic method of this compound is introduced below., Safety of 4-[1,2,4]Triazol-1-yl-benzoic acid

A mixture of MIICl2 (0.25mmol) (M=Zn(1), Cd(2)), ligand Hcpt (0.5mmol), and DMF (10mL) was heated at room temperature to 150C for three days in a 25mL Teflonlined stainless-steel autoclave and was then cooled to room temperature at 5C/h-1 to obtain corresponding colorless block crystals 1-2 (yield: 53% for 1 and 49% for 2 based on MII). Anal.Calcd for 1 C18H12N6O4Zn (441.71): C, 48.90; H, 2.72; N, 19.02%. Found: C, 48.86; H, 2.75; N, 19.07%. IR frequencies (KBr, cm-1): 3443 (w), 3131 (w), 1682 (s), 1608 (s), 1568 (m), 1542 (m), 1504 (m), 1492 (m), 1462 (w), 1427 (w), 1384 (s), 1297 (s), 1219 (m), 1142 (s), 1045 (s), 1068 (m), 1002 (w), 975 (m), 955 (m), 860 (m), 809 (w), 771 (m), 690 (w), 670 (m), 638 (w), 559 (w), 538 (w), 516 (w). Anal.Calcd for 2 C24H26O6N8Cd (634.94): C, 45.36; H, 4.09; N, 17.64%. Found: C, 45.35; H, 4.11; N, 17.69%. IR frequencies (KBr, cm-1): 3425(mb), 2918(w), 1683(m), 1650(m), 1607(s), 1523(s), 1476(m), 1412(m), 1385(s), 1265(s), 1203(m), 1181(w), 1062(w), 858(m), 784(m), 722(w), 653(w), 619(w), 535(w), 524(w).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Li, Teng; Liu, Xiang; Huang, Zhuang-Peng; Lin, Qiang; Lin, Chu-Ling; Zhan, Qing-Guang; Xu, Xiang-Dong; Cai, Yue-Peng; Inorganic Chemistry Communications; vol. 39; (2014); p. 70 – 74;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Brief introduction of 4928-87-4

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 4928-87-4, A common heterocyclic compound, 4928-87-4, name is 1,2,4-Triazole-3-carboxylic acid, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of (S)-4-(aminomethyl)-N-(4-chloro-2-(2-methyl-4-(3,3,3-trifluoropropyl)piperazin- l-yl)phenyl)-2,3-difluorobenzamide (0.08 g, 0.16 mmol), l/ -l ,2,4-triazole-3-carboxylic acid (0.10 g, 0.88 mmol) and DIPEA (0.2 mL, 1.1 mmol) in CH3CN (2.5 mL) was stirred at room temperature for 10 min, then HATU (0.08 g, 0.21 mmol) was added. And then the mixture was stirred at room temperature for 12 h and was purified by HPLC to give the title compound (0.033 g, 34.6%). LC/MS m/z = 586.1 [M+l]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; TRAN, Thuy-Anh; KRAMER, Bryan Aubrey; SHIN, Young-Jun; WO2014/182688; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Some tips on 956317-36-5

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 956317-36-5, A common heterocyclic compound, 956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid, molecular formula is C10H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

HATU (0.090 g, 0.24 mmol) was added to a solution of 2-[3-(5-fluoropyridin-2-yl)-1,2-oxazol-5-yl]ethanamine (0.053 g, 0.16mmol), 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid (0.038 g,0.19 mmol) and DIPEA (0.082 mL, 0.47 mmol) in DMF (5 mL),followed by stirring at room temperature for 16 h. An aqueousNaHCO3 solution was added to the reaction solution, followedby extraction with EtOAc. The organic layer was washed with brine and was dried over MgSO4. The desiccant was then removedby filtration, and the solvent was distilled off under reduced pressure.The resulting residue was purified by column chromatography(20-80% EtOAc in hexanes) to give the title compound 20 asa colorless powder (0.060 g, 97%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Suzuki, Ryo; Nozawa, Dai; Futamura, Aya; Nishikawa-Shimono, Rie; Abe, Masahito; Hattori, Nobutaka; Ohta, Hiroshi; Araki, Yuko; Kambe, Daiji; Ohmichi, Mari; Tokura, Seiken; Aoki, Takeshi; Ohtake, Norikazu; Kawamoto, Hiroshi; Bioorganic and Medicinal Chemistry; vol. 23; 6; (2015); p. 1260 – 1275;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The important role of 3179-31-5

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3179-31-5, name is 1H-1,2,4-Triazole-3-thiol, A new synthetic method of this compound is introduced below., Recommanded Product: 3179-31-5

Preparation 116; 2- (Thiazolo [3,2-b] [1, 2,4] triazol-6-yl) acetamide; Methyl 3-oxo-4- ( (rl, 2, 41iazol-3-yl) sulfanyl) butyrate; Add dropwise potassium tert-butoxide (11.4 g, 101. 8 mmol) in 30 ml N, N- dimethylformamide (30 ml) to a solution of [1, 2,4] triazole-3-thiol (10.3 gm, 101.8 mmol) in N, N-dimethylformamide (50 ml). Add dropwise methyl 4-chloroacetoacetate (15.3 gm, 101.8 mmol) in N, N-dimethylformamide (15 ml) and stir for 3 hours. Concentrate under reduced pressure, dilute with ethyl acetate (500 ml), filter, and concentrate under reduced pressure. Subject the residue to silica gel chromatography to provide the desired compound (18.3 gm, 83%) as a yellow oil. HRMS: m/z = 216.0443 (M++1)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ELI LILLY AND COMPANY; WO2003/76442; (2003); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Share a compound : 1001401-62-2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, other downstream synthetic routes, hurry up and to see.

Electric Literature of 1001401-62-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below.

A solution of 2-(2H-l,2,3-triazol-2-yl)benzoic acid (500 mg, 2.64 mmol) in SOCI2 (5 mL) was heated to reflux for 1 hour. After cooling to RT, the mixture was concentrated in vacuo to give a residue. To a solution of ((3R,6R)-6-methylpiperidin-3- yl)methanol hydrochloride (437 mg, 2.65 mmol) in toluene (5 mL) was added 1 N NaOH (5.3 mL), followed by a solution of the reaction residue in toluene (5 mL) dropwise. The resulting mixture was stirred at 10C for 12 h, then poured into water (5 mL) and extracted with EtOAc (5 mL x 3). The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (20-50 % EtOAc in petroleum ether) to afford the title compound as a solid. LRMS m/z (M+H) 301.1 found, 301.2 required.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; KUDUK, Scott, D.; LUO, Yunfu; MENG, Na; YU, Tingting; (83 pag.)WO2016/69510; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics